摘要
通过对相关文献的整理和总结,对外泌体在骨代谢中的作用机制与中医“肾主骨生髓”理论进行相关性分析,从现代分子生物学角度来探讨“肾主骨生髓”理论与骨质疏松症的关系。骨髓间充质干细胞的成骨分化在维持骨代谢平衡中起到了重要的作用,现代研究也证实,补肾药治疗骨质疏松症的机制与促进骨髓间充质干细胞的成骨分化密切相关。外泌体主要含有核酸、蛋白质及脂质等,可进行细胞间的物质交换与信号传导,是细胞通讯的重要介质之一。在现代研究中,外泌体主要是通过促进骨髓间充质干细胞的成骨分化来影响骨代谢。因此,外泌体与“肾主骨生髓”理论在功能上有一定的相关性,从外泌体探讨“肾主骨生髓”理论与骨质疏松症的关系,将为中医药防治骨质疏松症提供一种新的研究思路。
Through the collation and summary of the relevant literature,this paper analyzes the correlation between the mechanism of exosomes in bone metabolism and the theory of“kidney main bone producing marrow”in traditional Chinese medicine.To explore the relationship between the theory of“kidney main bone producing marrow”and osteoporosis from the point of view of modern molecular biology.The osteogenic differentiation of bone marrow mesenchymal stem cells plays an important role in maintaining the balance of bone metabolism.modern studies have also confirmed that the mechanism of kidney-tonifying drugs in the treatment of osteoporosis is closely related to the promotion of osteogenic differentiation of bone marrow mesenchymal stem cells.Exosomes mainly contain nucleic acids,proteins and lipids,which can carry out substance exchange and signal transduction between cells.It is one of the important mediators of cell communication.In modern research,exosomes affect bone metabolism mainly by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells.Therefore,there is a certain functional correlation between the exosome and the theory of“kidney main bone producing marrow”.This paper discusses the relationship between the theory of“kidney main bone producing marrow”and osteoporosis from the exosome,so as to provide a new research idea for the prevention and treatment of osteoporosis with traditional Chinese medicine.
作者
郭澜
李莉
葛继荣
GUO Lan;LI Li;GE Jirong(Fujian University of Traditional Chinese Medicine, Fuzhou 350003;Fujian Academy of Chinese Medical Scienses, Fuzhou 350003, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第12期1852-1856,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金项目(81674007)
福建省科技厅公益类科研院所基本科研专项(2018R1035-4)。
关键词
肾主骨生髓
外泌体
骨质疏松症
kidney main bone producing marrow
exosome
osteoporosis
作者简介
通讯作者:葛继荣,Email:gjrrjgcy@163.com。
