摘要
为了开展Ge-Ga发生器技术研究,需要开展^(68)Ge生产小试实验。本研究基于FLUKA蒙卡程序模拟了医用放射性核素68Ga的母体核素^(68)Ge的生产,计算了14、30、70 MeV质子束分别在100、200、500μA束流强度下照射富集69Ga的镓金属靶1、12、24 h后^(68)Ge的EOB(end of bombardment)产额,并对产额的变化以及靶上放射性核素活度进行分析。30 MeV/500μA质子束打靶24 h后^(68)Ge核素的EOB产额为3.13×10^(10) Bq,与70 MeV/500μA质子束的4.54×10^(10) Bq相当,但是靶上放射性杂质核素较少,30 MeV质子回旋加速器投入产出效益高。通过研究确定^(68)Ge核素生产的质子能量选择为30 MeV,可为^(68)Ge的生产小试实验及批量生产提供理论依据和技术支持。
With the development of nuclear science and technology,the application of PET medical radionuclides is increasing,and the demand is increasing.But the Ge-Ga generators used to provide 68Ga medical radionuclide are all dependent on imports.In order to carry out the research of Ge-Ga generator technology,we will carry out the pilot experiments of ^(68)Ge production.In the study,the simulated production of medical radionuclide ^(68)Ge based on FLUKA Monte Carlo program.The end of bombardment(EOB)yields of ^(68)Ge with 100μA,200μA and 500μA beam intensity were calculated by 14 MeV,30 MeV and 70 MeV proton beams irradiating Ga targets enriched with 69Ga for 1 hour,12 hours and 24 hours,respectively.The changes of EOB yields and the activity of radionuclides on the targets were analyzed.After 24 hours irradiation by 30 MeV/500μA proton beam,the EOB yield of ^(68)Ge nuclide is 3.13×10^(10) Bq,which is similar to the EOB yield with 24 hours irradiation by 70 MeV/500μA proton beam,which is 4.54×10^(10) Bq.There are fewer radioactive impurities on the target and higher input and output benefit with 30 MeV proton beams.Therefore,the proton energy for ^(68)Ge nuclide production is 30 MeV.The research could provide some theoretical basis and support for ^(68)Ge production pilot experiment and mass production.
作者
王哲
安世忠
赵云龙
王飞
官国英
陆潞
魏素敏
冀鲁豫
边天剑
WANG Zhe;AN Shizhong;ZHAO Yunlong;WANG Fei;GUAN Guoying;LU Lu;WEI Sumin;JI Luyu;BIAN Tianjian(China Institute of Atomic Energy,Beijing 102413,China)
出处
《同位素》
CAS
2024年第6期549-554,共6页
Journal of Isotopes
