摘要
随着中国人口老龄化趋势的增加,骨质疏松症的患病率也随之升高,运动训练作为一种安全、无创、有效的治疗手段,其治疗效果得到了广泛的认可,能够有效地预防和改善骨质疏松症,但其发病机制还尚不明确。本文就骨质疏松症的基本概述、诊断标准、参与骨质疏松症发病机制相关的信号通路(HIF-1α/VEGF信号通路、Wnt/β-catenin信号通路、OPG/RANKL/RANK信号通路)以及总结不同的运动训练对骨质疏松症的干预效果,为临床提供理论依据,提高中老年人对骨质疏松症的预防能力。
With the increasing trend of the aging population in China,the incidence of osteoporosis has also increased.Exercise training,recognized as a safe,non-invasive,and effective therapeutic approach,has been widely acknowledged for its therapeutic effects in preventing and improving osteoporosis,yet the pathogenesis remains not fully understood.This article provides a basic overview of osteoporosis,diagnostic criteria,and the signaling pathways associated with its pathogenesis(HIF-1α/VEGF signaling pathway,Wnt/β-catenin signaling pathway,OPG/RANKL/RANK signaling pathway).It also summarizes the intervention effects of different exercise training on osteoporosis,offering theoretical support for clinical practice and enhancing the ability of the elderly to prevent osteoporosis.
作者
龙怡凡
廖源
黄福锦
邹捷粮
文业千
郑博今
李迎红
Long Yifan;Liao Yuan;Huang Fujin;Zou Jieliang;Wen Yeqian;Zheng Bojin;Li Yinghong(Hunan University of Technology,Zhuzhou,Hunan 412007,China;Qingyuan Hospital Affiliated to Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan,Guangdong 511518,China;Department of Rehabilitation Medicine,the First Affiliated Hospital of Hengyang Medical College,University of South China,Hengyang,Hunan 421009,China;Affiliated Primary School of Zhuzhou Second Middle School,Zhuzhou,Hunan 412007,China)
出处
《齐齐哈尔医学院学报》
2024年第23期2285-2290,共6页
Journal of Qiqihar Medical University
基金
国家自然科学青年基金项目(82105022)
湖南省自然科学基金(2023JJ40586,2021JJ30616)。
关键词
骨质疏松症
运动训练
信号通路
Osteoporosis(OP)
Exercise training
Signaling pathways
Review
作者简介
通信作者:李迎红,Email:67287545@qq.com。
