摘要
随着肿瘤生物学的研究深入,人们逐渐认识到慢性炎症与肿瘤发生密不可分。在慢性病毒性肝炎,酒精性肝炎、非酒精性脂肪肝等导致肝细胞癌(hepatocellular carcinoma,HCC)发生的危险因素中,慢性非可控性炎症的发生发展是HCC发生的核心因素。肝脏在发生非可控性炎症的过程中,其发生的复杂多样的病理变化为肿瘤的发生提供了适宜的微环境。中医认为,肿瘤的发生以正虚为本,而炎-癌转化能够连续进行则是因为伏毒的潜藏与累积。本文主要以微环境为切入点探讨肝癌炎-癌转化的机制,基于“正虚伏毒”理论探讨肝癌炎-癌转化的中医病机,并结合名老中医朴炳奎教授治疗经验,探讨“扶正培本”与“调气解毒”思想在肝癌炎-癌转化的具体应用。
With the in-depth study of tumor biology,it has been gradually recognized that chronic inflammation is inextricably linked to tumor.Among the risk factors of hepatocellular carcinoma(HCC)such as chronic viral hepatitis,alcoholic hepatitis,and non-alcoholic fatty liver disease,the occurrence and development of chronic uncontrolled inflammation is a core factor in the occurrence of HCC.In the process of non-controllable inflammation,the complex and diverse pathological changes occurring in liver provide a suitable microenvironment for tumor.According to traditional Chinese medicine(TCM),tumorigenesis is based on healthy qi deficiency,while inflammation-cancer transformation can be carried out continuously because of the latent and accumulated toxin.This paper discussed the mechanism of inflammation-cancer transformation of hepatocellular carcinoma from the perspective of microenvironment and the TCM pathogenesis of inflammation-cancer transformation of liver cancer based on the theory of“healthy qi deficiency with latent toxin”,and combined the treatment experience of renowned TCM doctor PIAO Bingkui to explore the specific application of the ideas of“strengthening the healthy qi and nourishing the foundation”and“regulating qi and detoxifying”in inflammation-cancer transformation of liver cancer.
作者
李柏慧
杜炎远
蔡柳
马苏苏
郑红刚
LI Baihui;DU Yanyuan;CAI Liu;MA Susu;ZHENG Honggang(Clinical Medical College,Beijing University of Chinese Medicine,Beijing 100020,China;Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《中医肿瘤学杂志》
2024年第6期78-82,共5页
Journal of Oncology in Chinese Medicine
基金
国家中医药管理局中医药创新团队及人才支持计划项目(编号:ZYYCXTD-C-202205)。
关键词
正虚伏毒
炎-癌转化
微环境
肝癌
论治
healthy qi deficiency with latent toxin
inflammation-cancer transformation
microenvironment
liver cancer
treatment
作者简介
李柏慧(2000-),女,硕士研究生,研究方向:中医肿瘤防治研究。Email:19861401897@163.com;通信作者:郑红刚,博士研究生,主任医师,教授,研究方向:中医药防治恶性肿瘤的临床与基础研究。Email:honggangzheng@126.com。
