摘要
慢性阻塞性肺疾病(COPD)急性加重(AECOPD)是COPD自然病程中的重要不良事件,本研究利用超极化^(129)Xe MR技术探究了AECOPD疾病模型的肺泡微结构和气血交换功能变化.结果表明,相比于肺气肿组,急性加重组的肺部微结构变化不大,但气血交换功能显著下降.这些测量结果与组织学以及肺功能检查结果具有较好的相关性,证明了超极化^(129)Xe MR对AECOPD检测的可行性与灵敏性.
The acute exacerbation of chronic obstructive pulmonary disease(AECOPD)constitutes a significant adverse event in the trajectory of COPD.In this study,we utilized hyperpolarized^(129)Xe magnetic resonance(MR)to explore the alterations in alveolar microstructure and pulmonary gas exchange function in an AECOPD disease model.Our findings revealed that,in comparison to the emphysema group,the microstructure remained relatively unchanged in the acute exacerbation group,while gas exchange function exhibited a decrease.Notably,these observed changes correlated well with histological findings and pulmonary function assessments,indicating the feasibility and sensitivity of hyperpolarized^(129)Xe MR in detecting AECOPD.
作者
李连杰
郑瑜
谢树光
张鸣
李红闯
刘小玲
赵修超
韩叶清
李海东
范丽
萧毅
刘士远
周欣
LI Lianjie;ZHENG Yu;XIE Shuguang;ZHANG Ming;LI Hongchuang;LIU Xiaoling;ZHAO Xiuchao;HAN Yeqing;LI Haidong;FAN Li;XIAO Yi;LIU Shiyuan;ZHOU Xin(University of Shanghai for Science and Technology,Shanghai 200093,China;State Key Laboratory of Spectroscopy and Atomic and Molecular Physics,Wuhan Center for Magnetic Resonance,Innovation Academy for Precision Measurement Science and Technology,Wuhan 430071,China;Huazhong University of Science and Technology,Wuhan 430074,China;Department of Radiology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Medical Imaging,Xuzhou Medical University,Xuzhou 221000,China)
出处
《波谱学杂志》
CAS
2024年第4期363-372,共10页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金项目(81930049,82127802,21921004,82372150,82202119)
国家重点研发计划(2018YFA0704000,2022-YFC2410000)
湖北省科技重大专项(2021ACA013,2023BAA021)
中国科学院重点项目(ZDBS-LY-JSC004,XDB0540000)
中国科学院青年促进会专项(2020330,2021330).
作者简介
共同第一作者:李连杰;共同第一作者:郑瑜;通信作者:刘士远,Tel:027-87198631,E-mail:xinzhou@wipm.ac.cn;通信作者:周欣,Tel:021-81886012,E-mail:cjr.liushiuyuan@vip.163.com.
