摘要
Mesenchymal stem cell derived exosomes(MSC-Exos)demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties.Chitosan(CS)exhibits excellent biocompatibility and accelerates cellular migration,adhesion,and proliferation.The ions released from bioactive glass(BG)and titanium dioxide(TiO_(2))nanoparticles exhibit sustained angiogenic and antibacterial potency.In this study,CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan(CMCS),chitosan nanoparticles(CS-NPs),BG,and TiO_(2)nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects,diabetic wounds,and burn skin injury due to burns.In vitro analysis indicated that the hydrogel exhibits excellent cell compatibility,stimulates endothelial cell adhesion and proliferation,and presents anti-inflammatory,angiogenic,and antibacterial activities.In vivo,the composite hydrogel dressing accelerated a wound healing acceleration effect,stimulated angiogenesis,and increased collagen deposition and the expression of anti-inflammatory factors.This innovative composite hydrogel dressing as a potential clinical therapy,utilizing bioactive materials,holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.
基金
supported by National High Level Hospital Clinical Research Funding,(2023-NHLHCRF-YS-01)
Elite Medical Professionals Project of China-Japan Friendship Hospital(ZRJY2023-GG06)
the China Postdoctoral Science Foundation(Certificate Number:2023M733986 and 2023T160741)
Cross-sectional project of China-Japan Friendship Hospital(Certificate Number:2023-HX-JC-10)
International Association of Chinese Nephrologists Research Grant(No.IACNRG-01)
Beijing Hospitals Authority Clinical medicine Development of special funding support(Certificate Number:ZLRK202308).
作者简介
Shunlai Shang.E-mail addresses:18810568600@163.com;Kaiting Zhuang.E-mail addresses:2719059128@qq.com;Jianwen Chen.E-mail addresses:ilwincjw2015@126.com;Ming Zhang.E-mail addresses:cyyyzm@139.com;Corresponding author:Shimin Jiang.E-mail addresses:minjiang101@163.com;Corresponding author:Wenge Li.E-mail addresses:wenge_lee2002@126.com。
