摘要
糖尿病心肌病(diabetic cardiomyopathy,DCM)是糖尿病的主要心血管并发症,发病机制复杂,在临床仍缺乏有效的预防和治疗措施。近年来越来越多的研究表明,DCM时线粒体发生肿胀并伴有内部组织破坏,线粒体通过融合调节线粒体的结构和功能,参与了心肌结构和功能的调节,提示线粒体融合在DCM发生发展中发挥重要的作用。本研究系统阐述了线粒体融合通过调控线粒体动力学平衡、细胞凋亡、氧化应激以及胰岛素抵抗等重要生理过程影响DCM的病程进展的机制,旨在为DCM的防治提供新的思路和方法。
Diabetic cardiomyopathy(DCM)is a major cardiovascular complication of diabetes mellitus.The pathogenesis is complex,and there is still a lack of effective prevention and treatment measures in clinical practice.In recent years,more and more studies have shown that mitochondrial swelling and internal tissue destruction occur in DCM,and mitochondrial fusion regulates mitochondrial structure and function,which is involved in the regulation of myocardial structure and function,suggesting that mitochondrial fusion plays an important role in the occurrence and development of DCM.The present paper systematically described the mechanism of mitochondrial fusion affecting the progression of DCM by regulating mitochondrial dynamics,apoptosis,oxidative stress and insulin resistance,so as to provided new ideas and methods for the prevention and treatment of DCM in the future.
作者
张静
常盼
王姣
王红
ZHANG Jing;CHANG Pan;WANG Jiao;WANG Hong(Department of Cardiovascular Medicine,the Second Affiliated Hospital,Xi'an Medical Shool,Xi'an,Shaanxi 710038,China)
出处
《环境与健康杂志》
CAS
2024年第9期831-834,共4页
Journal of Environment and Health
基金
国家自然科学基金(82300407)
陕西省科技厅项目(2024JCYBQN-0766)
陕西省教育厅产业化项目(23JC059)。
关键词
线粒体
融合蛋白
糖尿病心肌病
Mitochondria
Fusion protein
Diabetic cardiomyopathy
作者简介
张静(1989-),女,硕士研究生,从事心血管机制研究;通信作者:王红,E-mail:381803502@qq.com。
