摘要
心血管病发病率高,死亡率高,经济、社会负担重,已成为亟待解决的重大公共卫生问题。线粒体质量控制是维持线粒体内稳态的基石,在心血管病进程中具有重要作用。有研究发现Sirt1/Sirt3信号参与了心肌线粒体质量控制作用机制,逐渐成为心血管病防治的重要靶点。同时,研究显示中药能够基于Sirt1/Sirt3信号调控心肌线粒体质量控制,改善心血管病,但尚不充分。因此,本文就Sirt1/Sirt3信号对心血管病线粒体质量控制影响的相关研究进行综述并结合中药提出新思路,以期为探讨心血管病作用靶点及中医药防治心血管病作用机制研究提供依据和方向。
Cardiovascular disease has become a major public health problem to be solved due to its high incidence rate,high mortality and heavy economic and social burden.Mitochondrial quality control is the cornerstone of maintaining mitochondrial homeostasis and plays an important role in the occurrence and progression of cardiovascular diseases.Some studies have found that Sirt1/Sirt3 signal is involved in the mechanism of myocardial mitochondrial quality control,and has gradually become an important target for cardiovascular disease prevention and treatment.At the same time,research shows that traditional Chinese medicine can regulate the quality control of myocardial mitochondria based on Sirt1/Sirt3 signal,and improve cardiovascular disease,but research is still insufficient.Therefore,this article reviews the research related to the influence of Sirt1/Sirt3 signal on the mitochondrial quality control of cardiovascular disease and proposes new ideas in combination with traditional Chinese medicine,with a view to providing a basis and direction for the research on the target of cardiovascular disease and the mechanism of traditional Chinese medicine in the prevention and treatment of cardiovascular disease.
作者
张泸丹
王彬
王新陆
朱明军
赵齐飞
Zhang Ludan;Wang Bin;Wang Xinlu;Zhu Mingjun;Zhao Qifei(Cardiac Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第11期3654-3659,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年科学基金项目(82004343):基于miR-199a-5p/Sirt1/Sirt3轴调控的线粒体质量控制探讨芪苈强心胶囊干预CHF心肌能量代谢的作用机制,负责人:赵齐飞
河南省卫生健康委员会河南省中医药科学研究专项课题(2019JDZX2027):人参总次苷对慢性心力衰竭大鼠心脏能量代谢干预作用及机制研究,负责人:赵齐飞
河南省人力资源和社会保障厅河南省博士后科研项目(202002076):基于线粒体质量控制探讨参附益心颗粒干预心力衰竭心肌能量代谢的作用机制,负责人:赵齐飞
关键词
心血管病
Sirt1/Sirt3信号
线粒体质量控制
中药
Cardiovascular disease
Sirt1/sirt3 signal
Mitochondria quality control
Traditional Chinese medicine
作者简介
通讯作者:赵齐飞,博士,主治医师,主要研究方向:中医药防治心血管疾病的临床及基础研究。
