摘要
目的分析王俊宏教授治疗儿童抽动障碍处方用药规律和学术思想。方法选择2015年1月-2022年11月王俊宏教授诊治的儿童抽动障碍病例,采用Excel2016分析患儿一般临床信息,多维度分析处方药物的频次排序、性味归经及变化。使用SPSS Modeler 18.0对2021、2022年处方进行药物关联规则分析,Cytoscape3.9.0对SPSS Modeler 18.0得出的药物-药物强、中、弱链接进行复杂网络分析。在SPSS中获得药物群组,使用Excel2016实现对高频药物的流年变化分析。结果共纳入处方5586首,涉及中药198味,总频次为108356。高频中药前5位为菊花、石菖蒲、黄连、白芍、远志,药性以寒、温、平为主,药味以苦、甘、辛为多,主要归肝经、心经、肺经。关联规则分析显示,常见对药有菊花-石菖蒲和石菖蒲-全蝎,常用角药有菊花-全蝎-石菖蒲。聚类分析显示出4个药物群组,体现了王俊宏教授平肝安神的治疗特点。流年变化分析显示,2020年以来,柴胡、黄芩、石决明、天麻、珍珠母等药物比例逐渐增加,提示治疗更多重视从肝论治及化痰、重镇安神。结论王俊宏教授治疗儿童抽动障碍以心、肝、肺为中心,处方用药以息风化痰、疏肝安神为治疗法则,近年来重视调畅情志及化痰在儿童抽动障碍治疗中的作用。
Objective To analyze the medication law and academic thoughts of Professor Wang Junhong in the treatment of tic disorders(TD)in children.Methods The cases of children with TD diagnosed and treated by Professor Wang Junhong from January 2015 to November 2022 were selected.Excel 2016 was used to analyze the clinical information of children with TD.The frequency ranking,property,taste and meridian tropism,and changes of prescription drugs were analyzed in multiple dimensions.SPSS Modeler 18.0 was used to analyze the drug association rules of prescriptions in 2021 and 2022.Cytoscape 3.9.0 was used to analyze the complex network of drug-drug strong,medium and weak links obtained by SPSS Modeler 18.0.The drug groups were obtained in SPSS,and Excel 2016 was used to analyze the annual changes of high-frequency drugs.Results Totally 5586 prescriptions were included,involving 198 kinds of Chinese materia medica,with a total frequency of 108356 times.The top five kinds of high-frequency Chinese materia medica were Chrysanthemi Flos,Acori Tatarinowii Rhizoma,Coptidis Rhizoma,Crataegi Fructus,Polygalae Radix.The medicinal properties were mostly cold,warm and mild.The medicinal tastes were mainly bitter,sweet and pungent.The main meridians of drugs were liver,heart and lung meridians.The association rule analysis showed that the common couplet medicines were Chrysanthemi Flos-Acori Tatarinowii Rhizoma and Acori Tatarinowii Rhizoma-Scorpio.Commonly used triple combination was Chrysanthemi Flos-Scorpio-Acori Tatarinowii Rhizoma.Clustering analysis showed 4 drug groups,reflecting the characteristics of Professor Wang Junhong’s treatment of calming liver and tranquilizing mind.According to the time-flow analysis,since 2020,the proportion of drugs such as Bupleuri Radix,Scutellariae Radix,Haliotidos Concha,Gastrodiae Rhizoma and Margaritifera Concha have gradually increased,indicating that more attention should be paid to treating the liver,resolving phlegm and calming the mind.Conclusion In the treatment of TD in children,Professor Wang Junhong takes heart,liver and lung as the center.The prescription medication is to relieve wind and phlegm,soothe the liver and tranquilize the mind.In recent years,it has attached importance to the role of regulating emotions and resolving phlegm in the treatment of children with TD.
作者
李园
刘远欧
翟睿
闫雨柔
姜妍琳
梁敬
王俊宏(指导)
LI Yuan;LIU Yuanou;ZHAI Rui;YAN Yurou;JIANG Yanlin;LIANG Jing;WANG Junhong(Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2024年第11期83-89,共7页
Chinese Journal of Information on Traditional Chinese Medicine
基金
第七批全国老中医药专家学术经验继承工作项目(2022年)。
关键词
抽动障碍
用药规律
流年分析
关联分析
聚类分析
王俊宏
tic disorders
medication law
time-flow analysis
association analysis
clustering analysis
Wang Junhong
作者简介
通讯作者:王俊宏,E-mail:drjhwang@bucm.edu.cn。
