摘要
目的探讨更年期女性发生前庭性偏头痛(vestibular migraine,VM)的影响因素及其与雌二醇及降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的相关性。方法选取2022年3月至2024年2月在山东第二医科大学附属医院就诊的更年期女性VM患者100例(更年期VM组),及同期更年期健康体检者100例(更年期对照组)。采用多因素logistic回归分析更年期女性发生VM的影响因素,采用Pearson相关性分析更年期女性VM与雌二醇及CGRP的相关性。结果200例患者,年龄41~59岁,平均(49.0±4.9)岁。与更年期对照组相比,更年期VM组雌二醇更低[(39.13±5.32)pg/ml比(81.94±5.98)pg/ml],CGRP更高[(88.47±8.45)pg/ml比(59.59±5.97)pg/ml],差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,雌二醇越低(OR=0.559,95%CI:0.189~0.809,P=0.003)、CGRP越高(OR=7.601,95%CI:2.193~14.348,P=0.001)的更年期女性发生VM的风险越高。Pearson相关性分析结果显示,偏头痛及眩晕的发作频率及其持续时间和雌二醇呈负相关,与CGRP呈正相关(P<0.05)。结论更年期女性VM患者血清雌二醇水平降低、CGRP水平升高,且是更年期女性发生VM的独立危险因素,偏头痛及眩晕的发作频率及其持续时间与雌二醇水平负相关,与CGRP水平正相关。
Objective To explore the influencing factors of vestibular migraine(VM)in menopausal female and its correlation with estradiol and calcitonin gene-related peptide(CGRP).Methods A total of 100 menopausal female patients with VM(menopausal VM group)in Affiliated Hospital of Shandong Second Medical University from March,2022 to February,2024 were selected,and 100 menopausal healthy physical examination subjects(menopausal control group)were selected.The influencing factors of VM in menopausal female was analyzed by logistic regression,and the correlation between estrogen CGRP levels and VM in menopausal female was analyzed by Pearson correlation coefficient.Results The age of 200 patients ranged from 41 to 59 years,with an average of(49.0±4.9)years.Compared with the menopausal control group,the serum estradiol level in the menopausal VM group was significantly decreased[(39.13±5.32)pg/ml vs.(81.94±5.98)pg/ml],and the CGRP level in the menopausal VM group was significantly increased[(88.47±8.45)pg/ml vs.(59.59±5.97)pg/ml],and the differences with statistically significant(P<0.05).Multifactorial logistic regression analysis showed that menopausal female with lower levels of estradiol(OR=0.559,95%CI:0.189-0.809,P=0.003)and higher levels of CGRP(OR=7.601,95%CI:2.193-14.348,P=0.001)were more likely to develop VM.Pearson analysis results showed that the frequency and duration of migraine and vertigo attacks were negatively correlated with estradiol levels,and positively correlated with CGRP levels(P<0.05).Conclusions Serum estradiol levels decrease and CGRP levels increase in menopausal female VM,which are independent risk factors for VM in menopausal female.The frequency and duration of migraine and vertigo are negatively correlated with estradiol levels,and positively correlated with CGRP levels.
作者
王亚丽
孙宝梅
韩婧洋
张晓彤
于新军
Wang Yali;Sun Baomei;HanJingyang;Zhang Xiaotong;Yu Xinjun(Department of Geriatric Medicine,Affiliated Hospital of Shandong Second Medical University,Weifang 261035,China)
出处
《北京医学》
CAS
2024年第8期644-647,共4页
Beijing Medical Journal
基金
潍坊市卫生健康委员会科研项目(WFWSJK-2022-291)。
关键词
前庭性偏头痛
更年期
雌二醇
降钙素基因相关肽
影响因素
vestibular migraine(VM)
menopause
estradiol
calcitonin gene-related peptide(CGRP)
influencing factors
作者简介
通信作者:于新军,Email:yuxinjun9030@163.com。
