摘要
目的分析沙库巴曲缬沙坦钠片与运动康复治疗联用对慢性心功能衰竭(后称“慢性心衰”)患者心功能和运动耐量的影响。方法纳入郑州大学附属郑州中心医院2022年5月至2024年5月收治的90例慢性心衰患者,按随机单双数抽签法划分组别,45例单数入对照组,予常规药物治疗;另外45例双数者入研究组,在常规药物治疗开展前提下进行运动康复治疗。对比两组治疗前后心功能指标[心输出量(CO)、每搏输出量(SV)、左室射血分数(LVEF)]、治疗前后运动耐量(6 min步行距离)、治疗有效率及治疗前后明尼苏达心功能不全生命质量量表评分(MLHFQ)。结果治疗前,两组各项心功能指标比较差异无统计学意义(P>0.05),治疗后,两组CO、SV、LVEF水平均高于治疗前,且研究组CO、SV、LVEF水平高于对照组,差异有统计学意义(P<0.05);治疗前,两组6 min步行试验结果比较差异无统计学意义(P>0.05),治疗后,两组6 min步行距离均长于治疗前,且研究组6 min步行距离长于对照组,差异有统计学意义(P<0.05);研究组治疗有效率(93.33%)高于对照组(71.11%),差异有统计学意义(P<0.05),治疗前,两组MLHFQ评分比较差异无统计学意义(P>0.05),治疗后,两组MLHFQ评分低于治疗前,且研究组MLHFQ评分低于对照组,差异有统计学意义(P<0.05)。结论常规药物联合运动康复治疗慢性心衰较为理想,对心功能恢复和运动耐量的提高均有正性影响,值得应用。
Objective To analyze the impact of sacubitril/valsartan sodium tablets combined with exercise rehabilitation on heart function and exercise tolerance in patients with chronic heart failure(hereafter referred to as"chronic heart failure").Methods Ninety patients with chronic heart failure admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from May 2022 to May 2024 were enrolled.The patients were divided into groups based on random odd and even numbers;45 odd-numbered patients were included in the control group and received conventional drug therapy,while the remaining 45 evennumbered patients were included in the study group and received exercise rehabilitation in addition to conventional drug therapy.Heart function indicators[cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF)],exercise tolerance(6-minute walking distance),treatment efficacy,and Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores were compared between the two groups before and after treatment.Results Before treatment,there were no statistically significant differences in heart function indicators between the two groups(P>0.05).After treatment,CO,SV,and LVEF levels were higher in both groups,with the study group showing higher levels than the control group(P<0.05).Before treatment,there were no statistically significant differences in the 6-minute walking test results between the two groups(P>0.05).After treatment,the 6-minute walking distance increased in both groups,with the study group showing a longer distance than the control group(P<0.05).The treatment efficacy rate in the study group(93.33%)was higher than that in the control group(71.11%)(P<0.05).Before treatment,there were no statistically significant differences in MLHFQ scores between the two groups(P>0.05).After treatment,MLHFQ scores were lower in both groups,with the study group showing lower scores than the control group(P<0.05).Conclusion The combination of conventional drug therapy and exercise rehabilitation is ideal for treating chronic heart failure,positively impacting heart function recovery and exercise tolerance,making it worthwhile to apply.
作者
张诚佳
ZHANG Chengjia(Fifth Ward of Cardiovascular Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450000,China)
出处
《临床研究》
2024年第11期66-69,共4页
Clinical Research
关键词
沙库巴曲缬沙坦钠片
运动康复
慢性心功能衰竭
心功能
运动耐量
sacubitril/valsartan sodium tablets
exercise rehabilitation
chronic heart failure
heart function
exercise tolerance
作者简介
张诚佳,男,主治医师,硕士研究生。研究方向:心力衰竭和冠心病方面。
