摘要
A particular type of endogenous noncoding RNAs known as circular RNAs(circRNAs)has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns.CircRNAs might play a role in various of biological processes.The identification of particular circRNAs dysregulated in pulmonary arterial hypertension(PAH)raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment.This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease.This study presented several potential circRNA targets as diagnostic biomarkers for PAH,discussed their biological functions,and addressed the challenges that need to be considered for their application in clinical settings.
基金
supported by“Hibah Penelitian Dana Masyarakat FKKMK UGM”grant No.1528/UN1/FKKMK/PPKE/PT/2024 and“Riset dan Inovasi Untuk Indonesia Maju Gelombang 4”grant No.172/IV/KS/11/2023-6815/UN1/DITLIT/Dit-Lit/KP.01.03/2023 received by Anggoro Budi Hartopo.
作者简介
Corresponding Author:Anggoro Budi Hartopo.Email:a_bhartopo@ugm.ac.id。
