摘要
布鲁氏菌病是一种世界范围流行的细菌性人兽共患传染病,由布鲁氏菌属细菌引起,给畜牧业生产和公共卫生安全带来了极大的威胁。外膜蛋白是布鲁氏菌主要的免疫和保护性抗原,与布鲁氏菌的毒力、免疫调节和胞内寄生等特性密切相关。本文对布鲁氏菌主要外膜蛋白的研究进展予以综述,从而促进对布鲁氏菌抗原特性的理解,为布鲁氏菌新型诊断方法的建立和疫苗设计提供参考。
Brucellosis,a worldwide epidemic bacterial zoonotic infectious disease caused by bacteria of the genus Brucella,jeopardizes livestock production and poses a major threat to public health safety.Among the various components of Brucella,the outer membrane proteins play crucial roles as the primary immune and protective antigens.These proteins are closely associated with Brucella’s virulence,regulation of the immune response,and ability to survive and multiply within host cells.This article summarizes recent research progress in the primary outer membrane proteins of Brucella,and offers a synthesized view of the current knowledge landscape.Understanding the antigenic characteristics of Brucella outer membrane proteins may substantially contribute to the establishment of new diagnostic methods and the design of new vaccines,thus potentially leading to more effective prevention strategies against brucellosis.The review provides a reference for future studies and may aid in brucellosis control efforts.
作者
辛雪强
佟彤
王玉金
盛宇杰
徐正中
陈祥
XIN Xue-qiang;TONG Tong;WANG Yu-jin;SHENG Yu-jie;XU Zheng-zhong;CHEN Xiang(Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou 225009,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture and Rural Affairs,Yangzhou University,Yangzhou 225009,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2024年第9期872-879,共8页
Chinese Journal of Zoonoses
基金
国家重点研发计划(No.2021YFD1800403)
江苏高等学校大学生创新创业训练计划项目(No.202311117042Z)
江苏高校优势学科建设工程项目(PAPD)。
关键词
布鲁氏菌
外膜蛋白
抗原特性
Brucella
outer membrane proteins
antigenic properties
作者简介
共同第一作者:辛雪强;共同第一作者:佟彤为;通讯作者:陈祥,Email:chenxiang@yzu.edu.cn,ORCID:0000-0002-9736-8180。
