摘要
目的探讨祛息灵对结直肠息肉治疗的临床效果及对肠道菌群、胃肠激素的影响。方法选取2021年5-11月收治的结直肠息肉切除术后患者82例,按随机数表法分为对照组与观察组,各41例。2组患者均行结直肠息肉切除术,对照组给予常规治疗,观察组在对照组基础上给予祛息灵治疗。观察2组患者的中医证候积分、肠道菌群数量、血清指标、复发率、临床疗效及不良反应发生情况。结果治疗后,2组患者中医证候积分、大肠杆菌数量、血清表皮生长因子(EGF)、血管活性肠肽(VIP)、P物质(SP)与总复发率较治疗前降低,且观察组优于对照组(P<0.05);2组双歧杆菌及乳酸杆菌数量、治疗总有效率较治疗前升高,且观察组优于对照组(P<0.05);2组均无血常规、肝肾功能及凝血功能异常等不良反应。结论祛息灵能够改善患者肠道菌群与胃肠激素水平,降低中医证候积分与息肉复发率,提高患者临床疗效,安全性较高。
Objective To explore the clinical efficacy of Quxiling in the treatment of colorectal polyps and its effects on intestinal floras and gastrointestinal hormones.Methods A total of 82 patients treated in our hospital after colorectal polyp resection from May 2021 to November 2021 were selected and divided into a control group and an observation group according to the random number table method,with 41 cases in each group.A colorectal polyp resection was performed in both groups.After the surgery,the control group was given a routine treatment,while the observation group was treated with Quxiling on that basis.The TCM syndrome scores,intestinal flora number,serum indexes,recurrence rate,clinical efficacy and occurrence of adverse reactions were observed in the two groups.Results After treatment,the TCM syndrome scores,Escherichia coli number,serum epidermal growth factor(EGF),vasoactive intestinal peptide(VIP),substance P(SP)and total recurrence rate were decreased in both groups,and the observation group was better than the control group(P<0.05).The number of bifidobacterium and lactobacillus and the total effective rate of treatment were increased in both groups,and the observation group was better than the control group(P<0.05).There were no adverse reactions such as abnormal blood routine test,liver and kidney function,or coagulation function in both groups.Conclusion Quxiling can improve the intestinal flora and gastrointestinal hormone levels of patients,reduce the TCM syndrome scores and polyp recurrence rate,improve the clinical efficacy,with a higher safety.
作者
赵志强
刘玉杰
王子琤
杨乾
钱娟娟
赵婉琳
张春巧
ZHAO Zhiqiang;LIU Yujie;WANG Zicheng;YANG Qian;QIAN Juanjuan;ZHAO Wanlin;ZHANG Chunqiao(Anorectal Department,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051 China)
出处
《吉林中医药》
2024年第10期1195-1198,共4页
Jilin Journal of Chinese Medicine
基金
河北省中医药管理局资助项目(2022180)。
关键词
祛息灵
结直肠息肉
中医证候积分
肠道菌群
胃肠激素
Quxiling
colorectal polyps
TCM syndrome score
intestinalflora
gastrointestinal hormone
作者简介
赵志强(1962-),男,主任医师,主要从事中医肛肠疾病临床研究。
