摘要
目的:分析丁苯酞联合依达拉奉右莰醇治疗急性脑梗死的疗效。方法:选取2022年1月至2023年1月期间本院诊治的80例急性脑梗死患者,随机分为两组,每组各40例。对照组静脉滴注丁苯酞20 mg·次^(-1),Bid;观察组在对照组基础上联合依达拉奉右莰醇30 mL·次^(-1),Qd,持续治疗14 d。分析比较两组临床疗效;治疗前、治疗14 d后采用酶联免疫吸附测定神经胶质纤维酸性蛋白(Glial fibrillary acidic protein,GFAP)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、血清髓鞘碱性蛋白(Myelin basic protein,MBP)、钙结合蛋白(Calcium�binding protein,S100B)水平,同时采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)以及改良Rankin量表(Modified Rankin Scale,mRS)分别评价神经功能缺损、恢复情况,并记录患者不良反应发生情况。结果:观察组的治疗总有效率显著高于对照组,NSE、S100B、GFAP、MBP、NIHSS评分、mRS评分均低于对照组(P<0.05)。两组不良反应发生率比较无显著差异(P>0.05)。结论:苯酞联合依达拉奉右莰醇治疗急性脑梗死,可提高治疗效果,降低神经损伤蛋白标志物的表达水平,促进患者神经功能恢复且安全性较高。
Objective:To analyze the efficacy of butylphthalide combined with edaravone and right camphanol in the treatment of acute cerebral infarction.Method:Eighty patients with acute cerebral infarction who were diagnosed and treated in our hospital from January 2022 to January 2023 were randomly divided into two groups,with 40 cases in each group.The control group received intravenous infusion of 20 mg of butylphthalide,Bid,and the observation group received continuous treatment for 14 days with edaravone and right camphanol 30 mL Qd,in addition to the control group.Analyze and compare the clinical efficacy of the two groups.Before and after 14 days of treatment,the levels of glial fibrillary acidic protein(GFAP),neuron specific enolase(NSE),serum myelin basic protein(MBP),and calcium-binding protein(S100B)were measured using enzyme-linked immunosorbent assay.The National Institutes of Health Stroke Scale(NIHSS)and the Modified Rankin Scale(mRS)were used to evaluate the neurological deficit and recovery,respectively.The occurrence of adverse reactions was also recorded.Results:The total effective rate of the observation group was significantly higher than that of the control group,and the scores of NSE,S100B,GFAP,MBP,NIHSS,and mRS were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Butylphthalein combined with edaravone and camphor can improve the therapeutic effect of acute cerebral infarction,reduce the expression level of protein markers of neurological injury,promote the recovery of neurological function in patients,and have high safety.
作者
周相峰
Zhou Xiang-feng(Department of Encephalopathy,Yanling Hospital of Traditional Chinese Medicine,Xuchang 461200,Henan,China)
关键词
急性心肌梗死
丁苯酞
依达拉奉右莰醇
神经功能
安全性
Acute myocardial infarction
Butylphthalein
Edaravone camphor
Neurological function
Safety
作者简介
周相峰,男,副主任医师,主要从事神经内科临床疾病的治疗,Email:13782284959@163.com。
