摘要
目的 对比分析低通量透析膜透析、高通量透析膜透析对尿毒症患者毒素清除、炎症因子、氧化应激状态的影响。方法 非随机选取2023年1—12月揭西县人民医院收治的100例行维持性血液透析(maintenance hemodialysis, MHD)尿毒症患者为研究对象,按照不同透析方式分为两组,各50例。对照组予以低通量透析膜透析,研究组予以高通量透析膜透析。比较两组治疗总有效率、治疗前后血液毒素指标、炎症因子指标与氧化应激状态指标。结果 研究组治疗总有效率为92.00%(46/50),高于对照组的74.00%(37/50),差异有统计学意义(χ^(2)=5.741,P<0.05)。治疗前两组血液毒素指标、炎症因子水平、氧化应激状态指标水平对比,差异无统计学意义(P均>0.05)。治疗后研究组血液毒素指标、炎症因子水平低于对照组,氧化应激状态指标水平高于对照组,差异有统计学意义(P均<0.05)。结论 MHD尿毒症患者接受高通量透析膜透析的治疗效果优于低通量透析膜透析,可提升尿毒症毒素、炎症因子的清除效果,改善患者氧化应激状态。
Objective The effects of low-flux dialysis and high-flux dialysis on toxin clearance,inflammatory factors and oxidative stress in uremia patients were compared and analyzed.Methods 100 patients with maintenance hemodi-alysis(MHD)treated in Jiexi People′s Hospital from January to December 2023 were non-randomly selected as the subjects,and they were divided into two groups according to different dialysis methods,with 50 patients in each group.The control group was given low-flux dialysis membrane dialysis,and the study group was given high-flux dialysis membrane dialysis.The total effective rate,blood toxin index,inflammatory factor index and oxidative stress index be-fore and after treatment were compared between the two groups.Results The total effective rate of the study group was 92.00%(46/50),higher than 74.00%(37/50)of the control group,and the difference was statistically significant(χ^(2)=5.741,P<0.05).There was no significant difference in the levels of blood toxin,inflammatory factors and oxidative stress between the two groups before treatment(all P>0.05).After treatment,the levels of blood toxin indexes and in-flammatory factors in the study group were lower than those in the control group,and the levels of oxidative stress state indexes were higher than those in the control group,the differences were statistically significant(all P<0.05).Conclu-sion The treatment effect of MHD uremia patients receiving high-flux dialysis membrane dialysis is better than that of low-flux dialysis membrane dialysis,which can improve the clearance effect of uremia toxins and inflammatory fac-tors,and improve the oxidative stress state of patients.
作者
蔡芳芳
张优创
邓志雄
杨云峰
张燕妮
赵利云
张巧荣
蔡佳杰
CAI Fangfang;ZHANG Youchuang;DENG Zhixiong;YANG Yunfeng;ZHANG Yanni;ZHAO Liyun;ZHANG Qiaorong;CAI Jiajie(Nephrology Department,Jiexi People's Hospital,Jieyang 515400,Guangdong,China)
出处
《系统医学》
2024年第15期29-32,共4页
Systems Medicine
基金
广东省揭阳市卫生健康局医学科学技术研究立项(揭市卫[2023]42号,序号79)。
关键词
维持性血液透析
尿毒症
毒素清除
炎症因子
氧化应激状态
Maintenance hemodialysis
Uremia
Hemotoxin removal
Inflammatory factors
Oxidative stress
作者简介
蔡芳芳(1985-),女,本科,主治医师,研究方向为临床医学。
