摘要
目的:观察坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片(芬吗通)对围绝经期综合征(PMS)患者性激素指标、内膜厚度及免疫功能的影响。方法:选取2021年12月—2023年12月仁怀市妇幼保健院收治的162例PMS患者。根据随机数表法将其分为观察组和对照组,各81例。对照组给予芬吗通治疗,观察组在对照组基础上给予坤泰胶囊。比较两组治疗后临床疗效,治疗前后性激素指标、内膜厚度、免疫功能及不良反应。结果:观察组总有效率为93.82%,显著高于对照组的82.72%,差异有统计学意义(P<0.05)。治疗后,两组卵泡刺激素(FSH)、黄体生成素(LH)水平均明显降低,雌二醇(E_(2))水平明显升高,观察组FSH、LH水平均低于对照组,E_(2)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组内膜厚度、CD3^(+)、CD4^(+)均升高,CD8^(+)明显降低,观察组CD3^(+)、CD4^(+)均高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:坤泰胶囊联合芬吗通治疗PMS效果可观,可显著改善患者血清性激素水平,改善免疫功能指标,且不会增加药物不良反应。
Objective:To observe the effects of Kuntai Capsules combined with Estradiol Tablets/Estradiol Dydrogesterone Tablets(Femostone)on sex hormone indexes,intimal thickness and immune function in patients with perimenopausal syndrome(PMS).Method:A total of 162 PMS patients admitted to the Gynecology Department of Renhuai Maternal and Child Health Hospital from December 2021 to December 2023 were selected.They were divided into observation group and control group according to random number table method,81 cases in each group.The control group was given Femostone treatment,and the observation group was given Kuntai Capsules based on the basics of control group.The clinical efficacy after treatment,sex hormone indexes,intima thickness,immune function before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of observation group was 93.82%,which was significantly higher than 82.72%of control group,and the difference was statistically significant(P<0.05).After treatment,the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)were significantly decreased,and the level of estradiol(E_(2))was significantly increased in both groups,the levels of FSH and LH in the observation group were lower than those in the control group,and the level of E_(2) was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,intimal^(+)^(+)^(+)^(+)^(+)thickness,CD3 and CD4 increased in both groups,while CD8 decreased significantly.CD3 and CD4 in the observation group were^(+)higher than those in the control group,and CD8 was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Kuntai Capsules combined with Femostone is effective in the treatment of PMS,which can significantly improve serum sex hormone levels and improve immune function indicators in the patients,without increasing adverse drug reactions.
作者
张传美
ZHANG Chuanmei(Renhuai Maternal and Child Health Hospital,Renhuai 564500,China)
出处
《中外医学研究》
2024年第26期137-140,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
围绝经期综合征
坤泰胶囊
芬吗通
性激素
内膜厚度
免疫功能
Perimenopausal syndrome
Kuntai Capsules
Femostone
Sex hormone
Endometrial thickness
Immune function
