摘要
根管系统解剖结构复杂及根管内感染微生物的残留常引起根管再次感染,导致根管治疗失败、患牙预后不佳。粪肠球菌(Ef)是根管再次感染中的重要致病菌,通过形成难以清除的生物膜及分泌多种毒力因子等参与根管再次感染及根尖周炎的发生发展。多年来,本领域国内外学者对Ef在根管再次感染中的致病机制及干预措施进行了大量的研究,并认识到除Ef外,多种微生物在根管再次感染中也发挥了重要作用,理解这些关键微生物间的相互作用有助于理解根管再次感染的病因及可能机制。Ef从检出率高被学者们“认识”,随着技术的发展和研究的深入,由于多种微生物也被检出,其经历了“被质疑”到“被再认识”的过程。本文旨在探讨根管再次感染中以Ef为主的微生物的重要作用,再认识根管再次感染中Ef的重要角色。
The anatomical complexity of the root canal system and the persistence of microbes within the root canal system often lead to the reinfection,resulting in the failure of root canal therapy and poor prognosis of affected teeth.Enterococcus faecalis(Ef)is the key pathogenic bacterium in secondary root canal infection,and is involved in the development of secondary root canal infection and apical periodontitis by forming biofilms that are difficult to remove and secreting a variety of virulence factors.For the past decades,extensive studies on the pathogenic mechanism and intervention measures of Ef in secondary root canal infection have been conducted,and researchers have recognized that besides Ef,various microorganisms also play an important role in secondary root canal infection.Therefore,understanding the interactions between these key microorganisms helps to better understand the possible etiology of secondary root canal infection.Ef has gone from being"recognized"for its high detection rate to being"questioned"and"re-recognized"as a variety of microorganisms have been detected with the development of the technology and further study.This article aims to discuss the important role of microorganisms dominated by Ef and to further understand the crucial role of Ef in secondary root canal infection.
作者
余擎
相豆豆
程小刚
李娜
吴昊泽
杨偲睿
张劢
王罗千慧
YU Qing;XIANG Dou-dou;CHENG Xiao-gang;LI Na;WU Hao-ze;YANG Si-rui;ZHANG Mai;WANG Luo-qianhui(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Operative Dentistry and Endodontics,School of Stomatology,The Fourth Military Medical University,Xi’an 710032,China)
出处
《牙体牙髓牙周病学杂志》
2024年第1期4-11,共8页
Chinese Journal of Conservative Dentistry
基金
国家自然科学基金面上项目(82170937)
国家自然科学基金青年科学基金项目(82301054,81800955)。
关键词
根管再次感染
粪肠球菌
致病机制
临床干预
微生物相互作用
secondary root canal infection
pathogenesis
Enterococcus faecalis(Ef)
clinical intervention
interspecies interactions
作者简介
通讯作者:余擎(1967-),男,汉族,浙江杭州人。教授,主任医师,博士生导师,E-mail:yuqing@fmmu.edu.cn。
