摘要
目的:探讨聚维酮碘含漱液和西帕依固龈液用于治疗急性智齿冠周炎的临床疗效。方法:选取2020年12月至2023年6月于西安交通大学口腔医院口腔综合科和西安市第九医院口腔科就诊的135例急性智齿冠周炎患者,采用完全随机设计分为A、B、C 3组,每组各45例。A组使用生理盐水和3%过氧化氢溶液交替进行冠周冲洗,B组使用聚维酮碘含漱液进行冠周冲洗,C组使用西帕依固龈液进行冠周冲洗。3组患者均连续治疗3 d,每日1次。比较3组治疗前后视觉模拟评分法(VAS)的疼痛评分及龈沟液内细胞因子的变化情况。结果:治疗后,3组VAS评分均降低(P<0.05),其中B、C组评分相较A组减少更明显(P<0.05),且B组评分显著低于C组(P<0.05)。治疗后,3组龈沟液中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)以及前列腺素E2(PGE2)细胞因子水平均显著降低(P<0.05),其中B、C组相较A组降低更明显(P<0.05);且与C组相比,B组降低更多(P<0.05)。3组龈沟液中肿瘤坏死因子-α(TNF-α)水平与治疗前相比无明显差异(P>0.05)。结论:聚维酮碘含漱液和西帕依固龈液治疗智齿冠周炎的临床疗效显著,均可作为传统冠周冲洗液的替代产品用来治疗急性智齿冠周炎,而使用聚维酮碘含漱液冲洗效果更佳,可以快速有效缓解患者疼痛。
AIM:To investigate the clinical efficacy of POvidone iodine gargle and Xipayi gingival consolidation gargle in the treatment of acute pericoronitis of wisdom teeth.METHODS:A total of 135 patients diagnosed with acute pericoronitis of wisdom teeth between December 2020 and June 2023 at the Department of General Dentistry,Xi'an Jiaotong University Hospital of Stomatology and Xi'an No.9 Hospital were enrolled and randomly assigned to three groups:A,B,C(n=45 per group).Group A was rinsed alternately with normal saline and 3%hydrogen peroxide solution,group B was rinsed with POvidone iodine gargle,and group C was rinsed with Xipayi gingival consolidation gargle.All patients underwent one treatment per day for three consecutive days.Changes in pain scores using the Visual Analogue Scale(VAS)and levels of gingival crevicular fluid cytokines before and after treatment were assessed and compared among the three groups.RESULTS:After treatment,VAS scores significantly decreased in all three groups(P<0.05).Reductions in pain were more pronounced in group B and C compared to group A(P<0.05)with group B showing a significant reduction than group C(P<0.05).Post-treatment levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and prostaglandin E2(PGE2)in gingival crevicular fluid were significantly lower across all groups(P<0.05).The decreases were greater in group B and C than group A(P<0.05),and Group B showed significantly lower cytokine levels than group C(P<0.05).No significant changes were observed in tumor necrosis factor-α(TNF-α)levels of the three groups in gingival crevicular fluid after treatment(P>0.05).CONCLUSION:Both POvidone iodine gargle and Xipayi gingival consolidation gargle demonstrated significant clinical efficacy in treating acute pericoronitis of wisdom teeth,serving as effective alternatives to conventional pericoronitis irrigation methods.Among them,POvidone iodine gargle provided superior outcomes in pain relief and anti-inflammatory effects.
作者
马和晴
屈凌寒
林彤
程政
陈诚
崔敏
姚天华
李珏丹
杨利洒
刘义闻
程百祥
MA He-qing;QU Ling-han;LIN Tong;CHENG Zheng;CHEN Cheng;CUI Min;YAO Tian-hua;LI Jue-dan;YANG Li-sa;LIU Yi-wen;CHENG Bai-xiang(Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases,Department of General Dentistry,College of Stomatology,Xi'an Jiaotong University,Xi'an 710004,China;不详)
出处
《牙体牙髓牙周病学杂志》
2025年第4期215-220,共6页
Chinese Journal of Conservative Dentistry
基金
中华口腔医学会西部口腔医学临床科研基金项目(CSA-W2020-10)
陕西省重点研发计划项目(2023-YBSF-123)。
关键词
聚维酮碘含漱液
西帕依固龈液
急性智齿冠周炎
冠周冲洗
龈沟液
POvidone iodine gargle
xipayi gingival consolidation gargle
acute pericoronitis of wisdom teeth
pericoronal irrigation
gingival crevicular fluid
作者简介
马和晴(2003-),女,汉族,陕西西安人。本科;通信作者:程百祥,E-mail:chengbaixiang@xjtu.edu.cn。
