摘要
目的 探讨泊沙康唑预防血液系统疾病患儿粒细胞缺乏期侵袭性真菌病(IFD)的效果。方法 回顾性分析2020年1月至2021年11月广西医大开元埌东医院收治的60例血液系统疾病粒细胞缺乏期患儿的临床资料,根据治疗方法不同分为对照组(n=25)和试验组(n=35)。对照组采用伏立康唑治疗,试验组采用泊沙康唑治疗。比较两组IFD发生率、肝肾功能指标[谷丙转氨酶(ALT)、直接胆红素(DBil)、血肌酐(SCr)]、不良反应。结果 与对照组比较,试验组IFD发生率更低(P <0.05)。治疗前,两组肝肾功能指标比较,差异无统计学意义(P> 0.05)。治疗后,试验组肝肾功能指标与治疗前比较,差异无统计学意义(P> 0.05)。治疗后,对照组ALT、DBil、SCr高于治疗前,且试验组ALT、DBil、SCr低于对照组(P <0.05)。与对照组比较,试验组不良反应总发生率更低(P <0.05)。结论 泊沙康唑对预防血液系统疾病粒细胞缺乏期患儿发生IFD具有一定的效果,还可降低不良反应发生率,减轻患儿肝肾功能损伤。
Objective To investigate the effect of Posaconazole on the prevention of invasive fungal disease(IFD)in the agranulocytic stage in children with hematological diseases.Methods Clinical data of 60 children with hematological diseases in the agranulocytic stage admitted to Kaiyuan Langdong Hospital of Guangxi Medical University from January 2020 to November 2021 were retrospectively analyzed,and they were divided into control group(n=25)and experimental group(n=35)according to different treatment methods.The control group was treated with Voriconazole,and the experimental group was treated with Posaconazole.The incidence of IFD,liver and kidney function indexes(alanine aminotransferase[ALT],direct bilirubin[DBil],serum creatinine[SCr]),and adverse reactions were compared between the two groups.Results Compared with the control group,the incidence of IFD in experimental group was lower(P<0.05).Before treatment,there were no significant differences in liver and kidney function indexes between the two groups(P>0.05).There were no significant differences in liver and kidney function indexes in experimental group before and after treatment(P>0.05).After treatment,ALT,DBil,SCr in control group were higher than those before treatment,and ALT,DBil,SCr in experimental group were lower than those in control group(P<0.05).Compared with control group,the total incidence of adverse reactions in experimental group was lower(P<0.05).Conclusion Posaconazole has a certain effect in preventing IFD in children with hematological diseases in the agranulocytic stage,and can also reduce the incidence of adverse reactions and alleviate the damage of liver and kidney function.
作者
谭嫦
TAN Chang(Kaiyuan Langdong Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530028,China)
出处
《妇儿健康导刊》
2024年第17期89-92,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
泊沙康唑
血液系统疾病
侵袭性真菌病
预防
Posaconazole
Hematological diseases
Invasive fungal disease
Prevention
