摘要
目的探讨血栓弹力图(TEG)和B型利钠肽(BNP)评估急性肺栓塞病情严重程度的临床价值。方法选取我院2022年5月~2023年4月收治的40例急性肺栓塞患者作为观察组,另选同期50例健康体检者作为对照组。观察组根据患者病情危险度分为低危组(n=18)、中危组(n=13)和高危组(n=9)。对所有研究对象进行TEG检查和BNP水平测定,对比分析TEG指标和BNP水平与患者病情严重程度的相关性及其对急性肺栓塞的预测价值。结果四组BNP水平、凝血反应时间(R)、最大血块强度(MA)、血液凝固时间(K)及凝固角(α)比较,差异有统计学意义(P<0.05)。随着病情加重,BNP水平、MA及α显著上升,R、K缩短。与对照组比较,低危组、中危组、高危组的BNP水平、MA及α显著上升,R、K缩短(P<0.05);且不同危险度分组间TEG指标和BNP水平两两比较均有显著差异(P<0.05)。Pearson相关性分析显示,BNP水平、MA及α与急性肺栓塞患者的病情严重程度呈正相关(P<0.05),而R、K与急性肺栓塞患者的病情严重程度呈负相关(P<0.05)。TEG指标联合BNP预测急性肺栓塞的灵敏度为92.36%,特异度为87.73%,较其他指标单独预测的价值更高。结论TEG和BNP可用于评估急性肺栓塞患者的病情严重程度,且二者联合检测对急性肺栓塞具有较高的预测价值。
Objective To investigate the clinical value of thrombelastogram(TEG)and B-type natriuretic peptide(BNP)in evaluating the severity of acute pulmonary embolism(APE).Methods 40 patients with APE admitted to our hospital from May 2022 to April 2023 were selected as the observation group,and 50 healthy subjects were included as the control group.The observation group was divided into low-risk group(n=18),medium-risk group(n=13)and high-risk group(n=9)according to the the risk of patients.TEG and BNP levels of all subjects were measured.The correlation between TEG indexes and BNP levels and the severity of APE and its predictive value for APE were analyzed.Results There were significant differences in BNP level,coagulation reaction time(R),maximum blood clot strength(MA),blood coagulation time(K)and coagulation angle(α)among the four groups(P<0.05).With the aggravation of the disease,the BNP level,MA andαincreased significancly,and R and K decreased.Compared with the control group,BNP level,MA andαwere increased in the low-risk group,medium-risk group and high-risk group,and R and K were shortened(P<0.05).There were significant differences in TEG indexes and BNP levels between different risk groups(P<0.05).Pearson correlation analysis showed that BNP level,MA andαwere positively correlated with the severity of APE patients(P<0.05),while R and K were negatively correlated with the severity of APE patients(P<0.05).The sensitivity and specificity of TEG indexes combined with BNP in predicting APE were 92.36%and 87.73%,which were higher than those of other indicators detection alone.Conclusion TEG and BNP can be used to evaluate the severity of patients with APE,and the combined detection of the two has a high predictive value for APE.
作者
蔡雨岐
王宇宏
CAI Yu-qi;WANG Yu-hong(Department of Respiratory Medicine,Jilin City Central Hospital,Jilin 132011,China)
出处
《医师在线》
2024年第9期48-51,共4页
Journal of Doctors Online
基金
吉林市医疗卫生指导性计划项目(20220404012)。
关键词
急性肺栓塞
血栓弹力图
B型利钠肽
病情评估
Acute pulmonary embolism
Thrombelastogram
B-type natriuretic peptide
Disease assessment
作者简介
通信作者:王宇宏,Email:1056632987@qq.com。
