摘要
目的分析血清胆碱酯酶(CHE)与白蛋白(ALB)比值对慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者通气治疗预后的影响。方法采用前瞻性研究方法,选取焦作煤业(集团)有限责任公司中央医院2020年5月至2023年4月接受双水平气道正压通气呼吸机(BiPAP)治疗的110例COPD合并Ⅱ型呼吸衰竭患者为研究对象。在治疗前检测患者CHE、ALB水平并计算二者比值,根据其预后结局分为预后良好组与预后不良组,比较两组患者的CHE、ALB、CHE/ALB及一般资料,采用logistic回归检验分析影响患者通气治疗结局的因素,并绘制受试者工作特征(ROC)曲线分析CHE、ALB、CHE/ALB对患者通气治疗预后结局的预测价值。结果110例患者中病死30例(27.27%)。两组血清CHE、ALB及CHE/ALB差异有统计学意义(P<0.05)。经logistic回归检验显示,血清CHE、ALB及CHE/ALB是患者通气治疗预后的影响因素(P<0.05)。ROC显示血清ALB对患者通气治疗预后预测价值较低,曲线下面积(AUC)为0.624,血清CHE及CHE/ALB对患者通气治疗预后具有中等的预测价值,AUC分别为0.784、0.804,以CHE/ALB的AUC最高。结论CHE/ALB能够作为COPD合并Ⅱ型呼吸衰竭通气治疗预后的预测指标。
Objective To analyze the effect of serum cholinesterase(CHE)to albumin(ALB)ratio on the prognosis of patients with chronic obstructive pulmonary disease(COPD)complicated with typeⅡrespiratory failure treated with ventilation.Methods A prospective research method was used to select 110 patients with COPD complicated with typeⅡrespiratory failure who were treated with bilevel positive airway pressure ventilation ventilator(BiPAP)in Central Hospital,Jiaozuo Coal Industry(Group)Co.,LTD.from May 2020 to April 2023 as the study subjects.Before treatment,the levels of CHE and ALB in patients were measured and the ratio was calculated.Based on their prognosis,they were divided into a good prognosis group and a poor prognosis group.CHE,ALB,CHE/ALB and baseline data were compared in both groups.Logistic regression test was used to analyze the factors affecting the outcome of ventilation therapy,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of CHE,ALB and CHE/ALB on the prognosis of ventilation therapy.Results Among the 110 patients,30 died(27.27%).There was a statistical significant difference in serum CHE,ALB,and CHE/ALB in both groups(P<0.05).According to logistic regression analysis,serum CHE,ALB,and CHE/ALB were influencing factors on the prognosis of patients undergoing ventilation therapy(P<0.05).ROC showed that serum ALB had a low predictive value for the prognosis of patients undergoing ventilation therapy,with an area under the curve(AUC)of 0.624.Serum CHE and CHE/ALB had moderate predictive value for the prognosis of patients undergoing ventilation therapy,with AUC of 0.784 and 0.804,respectively,with CHE/ALB having the highest AUC.Conclusion CHE/ALB can serve as a predictive indicator for the prognosis of ventilation therapy for COPD with typeⅡrespiratory failure.
作者
贺敏超
张秀风
邢双丽
HE Minchao;ZHANG Xiufeng;XING Shuangli(Department of Respiratory and Critical Care,Central Hospital,Jiaozuo Coal Industry(Group)Co.,LTD.,Jiaozuo 454000,China)
出处
《河南医学研究》
CAS
2024年第17期3180-3183,共4页
Henan Medical Research
关键词
慢性阻塞性肺疾病
Ⅱ型呼吸衰竭
血清胆碱酯酶
血清白蛋白
chronic obstructive pulmonary disease
typeⅡrespiratory failure
serum cholinesterase
serum albumin
