摘要
目的探讨噻托溴铵粉雾剂对慢性阻塞性肺气肿患者心肺功能及免疫、炎症介质的影响。方法选取2017年2月至2019年2月辽宁省人民医院呼吸内科收治的慢性阻塞性肺气肿患者82例作为研究对象,以信封法随机分为观察组和对照组,每组41例。对照组予以异丙托溴铵气雾剂治疗,观察组予以噻托溴铵粉雾剂治疗。比较两组治疗前后心肺功能、炎症介质、免疫指标变化情况。结果治疗后,观察组及对照组6min步行距离均明显高于治疗前,且观察组改善效果优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组用力肺活量(FVC)、第一秒钟用力呼气容积(FEV1)、第一秒钟用力呼气容积占预计值的百分比(FEV1%)水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CD3^+、CD8^+水平均低于对照组,CD4^+、CD4^+/CD8^+水平均高于对照组,差异有统计学意义(P<0.05)。结论噻托溴铵粉雾剂可有效改善慢性阻塞性肺气肿患者心肺功能,减轻炎症反应,提高免疫功能。
Objective To explore the effects of tiotropium bromide powder Spray on cardiopulmonary function,immune and inflammatory indexes in patients with chronic obstructive pulmonary emphysema.Methods From February 2017 to February 2019,82 patients with chronic obstructive pulmonary emphysema admitted to the respiratory department of Liaoning Provincial People’s Hospital were selected as the study objects.They were randomly divided into study group and control group by envelope method,with 41 cases in each group.The control group was treated with ipratropium bromide aerosol and the study group with tiotropium bromide powder aerosol.The changes of cardiopulmonary function,inflammatory index and immune index between the 2 groups before and after treatment were compared.Results After treatment,the 6-minute walking distance of the study group and the control group was significantly higher than that before treatment,and the improvement effects of the study group was better than that of the control group,the difference was statistically significant(P<0.05).After treatment,FVC,FEV1 and FEV1 as a percentage of expected value,were significantly higher than those in the control group(P<0.05).After treatment,the levels of IL-8 and TNF in the study group were significantly lower than those in the control group(P<0.05).After treatment,the levels of CD3^+and CD8^+in the study group were lower than those in the control group,and the levels of CD4^+and CD4^+/CD8^+were higher than those in the control group(P<0.05).Conclusion Tiotropium bromide powder spray can effectively improve cardiopulmonary function,reduce inflammatory response and improve immune function in patients with chronic obstructive pulmonary emphysema.
作者
彭伟
由继辉
PENG Wei;YOU Ji-Hui(Department of respiratory medicine,Liaoning Provincial People's Hospital,Shenyang 110016,China)
出处
《中国药物经济学》
2020年第1期114-116,120,共4页
China Journal of Pharmaceutical Economics
关键词
慢性阻塞性肺气肿
噻托溴铵粉雾剂
心肺功能
免疫功能
炎症反应
Chronic obstructive emphysema
Tiotropium bromide powder fog
Cardiopulmonary function
Immune function
Inflammatory response
