摘要
脓毒症相关急性肾损伤(SA-AKI)发病机制复杂,有研究显示,在SA-AKI的发病过程中,NOD样受体家族的NLRP3(NLRP3)被激活,进而增加白细胞介素1β (IL-1β)的产生,介导炎症反应的发展。因此,针对近年NLRP3/IL-1β信号通路在SA-AKI中的研究进展进行了综述,以期为阐述SA-AKI的发病机制提供新的思路,同时也为SA-AKI的诊断和治疗提供了新的策略。
The pathogenesis of sepsis-associated acute kidney injury(SA-AKI)is complex.Studies have shown that in the pathogenesis of SA-AKI,NLRP3 of the NOD-like receptor family is activated,which in turn increases the production of interleukin-1β,mediates the development of an inflammatory response.In this paper,the research progress of NLRP3/IL-1βsignaling pathway in SA-AKI was reviewed,in order to provide new ideas for elaborating the pathogenesis of SA-AKI,and strategies for the diagnosis and treatment of SA-AKI.
作者
孙崇翔
张诗元
李桂伟
SUN Chong-xiang;ZHANG Shi-yuan;LI Gui-wei(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300380,China)
出处
《内科急危重症杂志》
2024年第4期355-358,共4页
Journal of Critical Care In Internal Medicine
作者简介
通信作者:李桂伟,E-mail:li-guiwei@163.com,天津市西青区昌凌路88号。
