摘要
cGAS-STING信号通路是免疫系统中的关键调节因子,对肿瘤免疫治疗具有重要的研究和应用前景。该信号通路激活STING蛋白后,能够促进I型干扰素(IFN-I)的产生,并进一步影响树突细胞的成熟,增强T淋巴细胞和自然杀伤(NK)细胞的攻击力,从而连接先天免疫和适应性免疫反应。文章重点回顾了化学类STING激动剂以及中药成分对cGAS-STING信号通路的调节作用。这些研究不仅揭示了STING激动剂的分子机制,而且为开发新型免疫调节剂提供了理论基础。此外,文章还探讨了中药成分与现代药物设计的结合潜力,为未来免疫治疗的研究提供了新的视角和策略。
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway is a pivotal regulator within the immune system and holds significant potential for research and application in cancer immunotherapy.Upon activation of the STING protein by this pathway,it promotes the production of Type I interferons,which subsequently affects the maturation of dendritic cells and enhances the cytotoxic capabilities of T lymphocytes and natural killer cells,thereby bridging innate and adaptive immune responses.This review focuses on the regulatory effects of chemical STING agonists and the modulation of the cGAS-STING signaling pathway by components derived from traditional Chinese medicine(TCM).These studies not only elucidate the molecular mechanisms of STING agonists but also provide a theoretical foundation for the development of novel immunomodulatory agents.Furthermore,this review discusses the potential integration of TCM components with modern drug design,offering new perspectives and strategies for future research in immunotherapy.
作者
赵凤
李雪
王蕊
王玉明
李云飞
ZHAO Feng;LI Xue;WANG Rui;WANG Yuming;LI Yunfei(College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《天津中医药大学学报》
CAS
2024年第8期762-768,共7页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家自然科学基金项目(82374300)。
关键词
STING激动剂
中药类STING激动剂
cGAS-STING信号通路
stimulator of interferon genes agonist
traditional Chinese medicine-derived sting agonists
cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway
作者简介
赵凤(1998-),女,硕士研究生在读,主要研究方向为中药药剂学;通讯作者:王玉明,E-mail:wangyuming226@163.com;通讯作者:李云飞,E-mail:liyunfei@tjutcm.edu.cn。
