摘要
目的探讨香果健消片治疗功能性消化不良(FD)的作用机制。方法利用中药系统药理学数据库与分析平台(TCMSP)和中医百科全书(ETCM)数据库获取香果健消片主要化学成分;构建化学成分与疾病靶点网络得到潜在靶点;对核心靶点进行基因本体(GO)功能富集分析和京都基因和基因组百科全书(KEGG)通路富集分析,最后进行分子对接验证。结果本研究筛选出21个有效成分和67个共同靶点。丝裂原活化蛋白激酶3(MAPK3)、表皮生长因子受体(EGFR)、非受体酪氨酸激酶(SRC)、肿瘤坏死因子(TNF)、蛋白激酶1(AKT1)等是香果健消片治疗FD的核心靶点。GO富集分析共得到367个条目,KEGG通路富集分析共得到116条通路,其中EGFR、磷脂酰肌醇3激酶-蛋白激酶B(PI3K/AKT)和C型凝集素受体(CLR)等通路可能与FD相关。结论香果健消片可能通过促进胃动力,改善胃肠道功能,从而治疗FD。
Objective To investigate the action mechanism of Xiangguo Jianxiao tablets on functional dyspepsia(FD).Methods The main chemical components of Xiangguo Jianxiao tablets were obtained by traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)and encyclopedia of traditional Chinese medicine(ETCM)databases.Potential targets were obtained by constructing a network of chemical components and disease targets.Gene ontology(GO)function enrichment analysis and Kyoto Encyclopedia of genes and Genomes(KEGG)pathway enrichment analysis were carried out on the core target,and finally molecular docking verification was performed.Results In this research,21 effective components and 67 common targets were screened out.Mitogen-activated protein kinase 3 gene,epidermal growth factor receptor(EGFR),SRC protooncogene(SRC),tumor necrosis factor(TNF),and protein kinase AKT1(AKT1)were the core targets of Xiangguo Jianxiao tablets in the treatment of FD.There were 367 entries in GO enrichment analysis and 116 pathways in KEGG pathway enrichment analysis,in which EGFR,phosphatidylinositide 3-kinases-protein kinase B(PI3K/AKT),C-type lectin-like receptor(CLR),etc.,pathways may be related to FD.Conclusion Xiangguo Jianxiao tablets may treat FD by promoting gastric motility and improvin g gastrointestinal function.
作者
孙晓娟
唐新宗
何丽芳
SUN Xiaojuan;TANG Xinzong;HE Lifang(YunNan YunHe Pharmaceutical Co.,Ltd.,Yunnan,Gejiu 661000,China)
出处
《中国医药科学》
2024年第15期74-78,共5页
China Medicine And Pharmacy
关键词
香果健消片
功能性消化不良
网络药理学
分子对接
作用机制
Xiangguo Jianxiao tablets
Functional dyspepsia
Network pharmacology
Molecular docking
Action mechanism
作者简介
通讯作者:何丽芳。
