摘要
目的探究羧甲司坦联合哌拉西林钠他唑巴坦钠治疗支气管扩张的效果及对患者血气分析指标、炎症相关指标的影响。方法队列研究。抽取2020年9月至2023年7月榆林市中医医院收治的80例支气管扩张患者,按照随机数字表法分为对照组和联合组,每组40例。对照组予以哌拉西林钠他唑巴坦钠治疗,联合组基于对照组予以羧甲司坦治疗。比较两组治疗效果、不良反应发生率、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]及炎症相关指标[降钙素原(PCT)、白细胞介素-33(IL-33)、C反应蛋白(CRP)、人中性粒细胞防御素1-3(HNP1-3)]。结果联合组总有效率(95.00%,38/40)高于对照组(77.50%,31/40),P<0.05。治疗7 d后,联合组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);治疗7 d后,联合组PCT、IL-33、CRP、HNP1-3水平低于对照组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论哌拉西林钠他唑巴坦钠联合羧甲司坦治疗支气管扩张效果显著,可减轻机体炎症,改善血气指标,安全性较高。
Objective To investigate the effect of carbocysteine combined with piperacillin sodium and tazobactam sodium in the treatment of bronchiectasis,and to analyze the influence on blood gas analysis indexes and inflammatory factors.Methods A total of 80 patients with bronchiectasis admitted to Yulin Hospital of Traditional Chinese Medicine from September 2020 to July 2023 were selected for the cohort study.And they were divided into a control group and a combined group according to random number table method,with 40 cases in each group.The control group was treated with piperacillin sodium and tazobactam sodium,and the combined group was treated with carbocysteine based on the treatment of the control group.The treatment efficacy,incidence of adverse reactions,blood gas analysis indexes,including arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and arterial oxygen saturation(SaO_(2)),inflammatory factors,including procalcitonin(PCT),interleukin-33(IL-33),C-reactive protein(CRP)and human neutrophil peptide 1-3(HNP1-3),were compared between the two groups.Results The total effective rate of the combined group(95.00%,38/40)was higher than that of the control group(77.50%,31/40),P<0.05.After 7 days of treatment,PaO_(2)and SaO_(2)in the combined group were higher than those in the control group,while PaCO_(2)in the combined group was lower than that in the control group(P<0.05).After 7 days of treatment,the levels of PCT,IL-33,CRP and HNP1-3 in the combined group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Piperacillin sodium and tazobactam sodium combined with carbocysteine is effective in the treatment of bronchiectasis,which can reduce inflammation and improve blood gas indexes,with high safety.
作者
冯辽辽
柏江锋
成伟平
Feng Liaoliao;Bai Jiangfeng;Cheng Weiping(Department of Infectious Diseases,Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,China;Department of Internal Medicine of Integrated Traditional Chinese and Western Medicine,Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,China;Department of Pharmacy,the Second Hospital of Yulin,Yulin 719000,China)
出处
《中国实用医刊》
2024年第12期84-87,共4页
Chinese Journal of Practical Medicine
基金
陕西省科技成果项目(9612022Y3045)。
作者简介
通信作者:成伟平,Email:liaonewlife9@163.com。
