摘要
经典名方宣郁通经汤(XTD)收载于明末清初傅山所著《傅青主女科》,该方具有疏肝泻火,理气养血之功效,主治肝郁化火之经前腹痛症,症见经前腹痛,少腹为甚,经来多紫黑瘀块者,其临床疗效确切且应用广泛。关于XTD的临床应用报道较多,而质量控制和系统性综述尚无报道。故本文将从化学成分、临床应用对XTD进行综述。并根据中药质量标志物的“五原则”对XTD的质量标志物进行预测,提示芍药苷、芍药内酯苷、苯甲酰芍药苷、藁本内酯、阿魏酸、丹皮酚、栀子苷、京尼平苷酸、α-香附酮、姜黄素、柴胡皂苷A、柴胡皂苷C、柴胡皂苷D、黄芩苷、黄芩素、汉黄芩素、千层纸素A、芥子碱硫氰酸盐、甘草苷、甘草酸可作为XTD的质量标志物,为XTD的质量控制及后续制剂开发提供理论依据。
The classic prescription Xuanyu Tongjing Decoction(XTD)is included in the Fuqingzhu Nvke written by Fu Shan in the late Ming and early Qing dynasties.It has the functions of soothing the liver and purging fire,regulating qi and nourishing blood,and is used to treat premenstrual abdominal pain caused by stagnation of the liver and resolving fire,the less abdomen is very,the more purple and black stasis,its clinical curative effect is definite and widely used.There are many reports on the clinical application of XTD,while quality control and systematic reviews have not been reported.Research progress on chemical constituent and clinical application of XTD were reviewed in this paper.According to"five principles",the quality markers of XTD were predicted in this paper.The results suggested that paeoniflorin,albiflorin,benzoylpaeoniflorin,ligustilide,ferulic acid,paeonol,geniposide,geniposidic acid,α-cyperone,curcumin,saikosaponin A,saikosaponin C,saikosaponin D,baicalin,baicalein,wogonin,oroxylin A,sinapine thiocyanate,liquiritin and glycyrrhizic acid could be used as quality markers of XTD,which could provide theoretical basis for the quality control and follow-up preparation development of XTD.
作者
翟张喜
孙建慧
常丽静
田真真
李艳英
ZHAI Zhangxi;SUN Jianhui;CHANG Lijing;TIAN Zhenzhen;LI Yanying(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Beijing Increase Innovative Drug Co.Ltd.,Beijing 102200,China;Beijing Increase Pharm Drug Co.Ltd.,Beijing 102200,China)
出处
《中国当代医药》
CAS
2024年第21期15-20,28,共7页
China Modern Medicine
关键词
宣郁通经汤
化学成分
临床应用
质量标志物
Xuanyu Tongjing Decoction
Chemical composition
Clinical application
Quality marker
作者简介
翟张喜(1996-),男,河北邯郸人,天津中医药大学研究生院2021级中药学专业在读硕士研究生,研究方向:中药新药与质量控制;通讯作者:李艳英(1979-),女,河北保定人,博士,高级工程师,硕士研究生导师,研究方向:中药新药与质量控制。
