摘要
目的对比米非司酮与戈舍瑞林在子宫内膜异位症(EM)患者腹腔镜术后的应用效果。方法选取在我院行腹腔镜手术的90例EM患者,随机分为A组(45例,术后米非司酮口服治疗)和B组(45例,术后戈舍瑞林皮下注射治疗),两组均连续用药6个月,且术后均随访1年。比较两组的性激素水平、子宫动脉血流参数、妊娠率及复发率。结果治疗6个月后,A组血清促卵泡激素(FSH)、雌二醇(E_(2))水平低于B组(P<0.05)。治疗6个月后,A组子宫动脉搏动指数(PI)、阻力指数(RI)低于B组,而收缩期峰值血流速度(PSV)高于B组(P<0.05)。术后随访期间,A组妊娠率高于B组(P<0.05);两组复发率比较差异无统计学意义(P>0.05)。结论与戈舍瑞林相比,米非司酮治疗腹腔镜术后EM患者的效果更好,可明显改善其性激素水平及子宫动脉血流情况,提高妊娠率。
Objective To compare the application effects of mifepristone and goserelin in patients with endometriosis(EM)after laparoscopic surgery.Methods 90 EM patients with laparoscopic surgery in our hospital were selected and randomly divided into group A(45 cases,treated with mifepristone orally after surgery)and group B(45 cases,treated with goserelin subcutaneous injection after surgery).Both groups were treated continuously for 6 months and followed up for 1 year after surgery.The sex hormone levels,uterine artery blood flow parameters,pregnancy rate and recurrence rate were compared between the two groups.Results After 6 months of treatment,the serum follicle stimulating hormone(FSH)and estradiol(E_(2))levels of group A were lower than those of group B(P<0.05).After 6 months of treatment,the uterine artery pulsatility index(PI)and resistance index(RI)of group A were lower than those of group B,and the peak systolic blood flow velocity(PSV)was higher than that of group B(P<0.05).During the follow-up after surgery,the pregnancy rate of group A was higher than that of group B(P<0.05);No statistical difference was found in the recurrence rate between the two groups(P>0.05).Conclusions Compared with goserelin,mifepristone has better treatment effect on EM patients after laparoscopic surgery,which can significantly improve the sex hormone levels,uterine artery blood flow,and pregnancy rate.
作者
袁婷婷
吴鹤立
潘学景
卢秋阳
YUAN Tingting;WU Heli;PAN Xuejing;LU Qiuyang(Department of Obstetrics and Gynecology,Nanyang Center Hospital,Nanyang 473000,China)
出处
《临床医学工程》
2024年第7期835-836,共2页
Clinical Medicine & Engineering
作者简介
袁婷婷(1995-),女,河南南阳人,硕士研究生学历,住院医师,研究方向:妇科肿瘤。
