摘要
目的 研究低剂量注射用甲泼尼龙琥珀酸钠(MSSI)治疗小儿脓毒血症的临床效果及对其预后的影响。方法 选取2020年7月-2023年7月天津市儿童医院重症医学科收治的90例脓毒血症患儿,经随机数字表法分为对照组(45例)与观察组(45例),对照组行常规治疗,观察组在其基础上加用低剂量MSSI治疗,比较两组临床治疗效果[序贯器官衰竭估计(SOFA)]、血流动力学指标[心率(HR)、平均动脉压(MAP)]、血清炎性因子[降钙素原(PCT)]、预后情况(ICU住院时间、住院时间、休克发生率、28 d病死率)。结果 两组治疗后SOFA评分均低于治疗前,且观察组SOFA评分低于对照组(P<0.05)。两组治疗后HR小于治疗前,MAP高于治疗前,且观察组HR小于对照组,MAP高于对照组(P<0.05)。两组治疗后PCT低于治疗前,且观察组PCT低于对照组(P<0.05)。观察组ICU住院时间、住院时间短于对照组(P<0.05),休克发生率小于对照组(P<0.05),两组28 d死亡率均为0。结论 低剂量MSSI对小儿脓毒血症具有确切治疗效果,可缓解病情,恢复患儿血流动力学水平,减轻其体内炎症,降低休克风险,加速预后康复。
Objective To study the clinical effect of low-dose methylprednisolone sodium succinate for injection(MSSI)in the treatment of pediatric sepsis and its effect on prognosis.Methods A total of 90 children with sepsis admitted to the Intensive Care Unit of Tianjin Children's Hospital from July 2020 to July 2023 were selected and divided into control group(45 children)and observation group(45 children)by random number table method.The control group received routine treatment,and the observation group was treated with low-dose MSSI on the basis of the control group.The clinical treatment effects[sequential organ failure assessment(SOFA)],hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)],serum inflammatory factors[procalcitonin(PCT)],prognosis(ICU hospitalization time,hospitalization time,shock incidence,28-day mortality)were compared between the two groups.Results After treatment,the SOFA scores of the two groups were lower than those before treatment,and the SOFA scores of the observation group were lower than those of the control group(P<0.05).After treatment,HR in the two groups was less than that before treatment,MAP was higher than that before treatment,and HR in the observation group was less than that in the control group,MAP was higher than that in the control group(P<0.05).After treatment,the PCT of the two groups were lower than those before treatment,and the PCT of the observation group were lower than those of the control group(P<0.05).The ICU hospitalization time and hospitalization time of the observation group were shorter than those of the control group(P<0.05),and the incidence of shock was lower than that of the control group(P<0.05).The 28-day mortality of the two groups was 0.Conclusion Low-dose MSSI has a definite therapeutic effect on sepsis in children,which can alleviate the condition,restore the hemodynamic level of children,reduce the inflammation in the body,reduce the risk of shock,and accelerate the recovery of prognosis.
作者
尚滢
SHANG Ying(Intensive Care Unit,Tianjin Children's Hospital,Tianjin 300134,China)
出处
《医学信息》
2024年第14期130-133,共4页
Journal of Medical Information
关键词
小儿脓毒血症
注射用甲泼尼龙琥珀酸钠
低剂量
血清炎性因子
血流动力学
pediatric sepsis
Methylprednisolone sodium succinate for injection
Low dose
Serum inflammatory factors
Hemodynamics
作者简介
尚滢(1991.4-),女,天津人,本科,住院医师,主要从事儿科重症医学临床工作。
