摘要
目的探讨CVVHDF与CVVH在脓毒血症伴急性肾功能衰竭中的应用效果。方法选取我院收治86例脓毒血症伴急性肾功能衰竭患者,选取时间:2019年5月~2021年5月,对照组(43例)和观察组(43例)(按照随机数字表法)。对照组采用CVVH治疗,观察组采用CVVHDF治疗。两组连续治疗7 d。比较两组入住ICU天数、总住院天数、治疗前后APACHEⅡ评分、排尿量、血清Cr、BUN、hs-CRP、β2-MG水平及治疗后不良反应发生情况。结果与治疗前比,治疗后两组APACHEⅡ评分、血清β2-MG、Cr、BUN、hs-CRP水平均降低,且观察组低于对照组;治疗后两组排尿量均增多,观察组多于对照组;治疗后观察组不良反应总发生率为6.98%,低于对照组27.91%(P<0.05)。结论CVVHDF应用于脓毒血症伴急性肾功能衰竭可改善患者机体炎症反应,减少不良反应,对小分子溶质的清除效果优于CVVH。
Objective To investigate the effect of CVVHDF and CVVH in septic patients with acute renal failure.Methods 86 septic patients with acute renal failure selected from May 2019 to May 2021 were divided into two groups,namely control group(43 cases)and observation group(43 cases)according to the random number table method.The control group was treated with CVVH and the observation group was treated with CVVHDF.The two groups were treated for 7 days.The length of stay in ICU,total length of stay,APACHE Ⅱ score,urine output,serum Cr,bun,hs-CRP,β2-MG level and adverse reactions after treatment.Results Compared with before treatment,the levels of β2-MG,Cr,bun and hs-CRP in the observation group were lower than those in the control group.After treatment,the urine output of the two groups increased,and the observation group was more than that of the control group.After treatment,the total incidence of adverse reactions in the observation group was 6.98%,which was lower than 27.91%in the control group(P<0.05).Conclusions The application of CVVHDF in septic patients with acute renal failure can improve the inflammatory response and reduce adverse reactions,and the clearance effect of small molecular solute is better than CVVHDF.
作者
方文西
林秋劲
吕祥
Fang Wenxi;Lin Qiujin;Lv Xiang(Department of Critical Medicine,Guangdong Haifeng pengpai Memorial Hospital,Shanwei,China;Inner Four Districts,Guangdong Haifeng pengpai Memorial Hospital,Shanwei,Chin)
作者简介
通信作者:方文西,E-mail:17026340623@163.com
