摘要
制备了基于脂质包裹中空介孔二氧化硅纳米粒的姜黄素递药系统(CUR-HMSN@lip),对其处方工艺参数进行优化,并考察了在大鼠体内的药动学行为。采用TEM、PXRD、ζ电位和热重分析法对CUR-HMSN@lip进行表征,结果说明负载姜黄素的中空介孔二氧化硅纳米粒(CUR-HMSN)成功被磷脂包裹。口服给予大鼠CUR-HMSN@lip后,tmax为(1.83±0.41)h,AUClast为(570.82±48.07)h·ng·mL–1,MRTlast为(5.68±1.21)h;与CUR-HMSN处理组相比,CUR-HMSN@lip处理组的药-时曲线未出现双峰现象;CUR-HMSN@lip的相对生物利用度为203.8%。该研究表明,CUR-HMSN@lip递药系统能提高姜黄素的生物利用度,改善CUR-HMSN的突释现象。
A drug delivery system of lipid-coated hollow mesoporous silica nanoparticles for curcumin(CUR-HMSN@lip)was constructed.Its formulation and process parameters were optimized,and its pharmacokinetic behavior in rats was investigated.The obtained CUR-HMSN@lip was characterized by TEM,PXRD,S potential,and thermogravimetric analyses,and the results indicated that the curcumin-loaded hollow mesoporous silica nanoparticles(CUR-HMSN)were successfully encapsulated by phospholipids.After orally administered of CUR-HMSN@lip to rats,the pharmacokinetic parameters of curcumin were determined and calculated.The results were as follows:tmax was(1.83±0.41)h,AUCiast was(570.82±48.07)h:ng'mL-',and MRTast was(5.68±1.21)h.Compared with the CUR-HMSN treatment group,the plasma concentration-time curve of the CUR-HMSN@lip treatment group did not show a double peak phenomenon.The relative bioavailability of CUR-HMSN@lip was 203.8%.It was concluded that the CUR-HMSN@lip delivery system increased the bioavailability of curcumin and improved the burst release of CUR-HMSN.
作者
程子明
薛雪
CHENG Ziming;XUE Xue(Tongfang Pharmaceutical Group Co.,Ltd.,Beijing 102100;Yuekang Pharmaceutical Group Co.,Ltd.,Beijing 100176)
出处
《中国医药工业杂志》
EI
CAS
CSCD
2024年第6期837-843,共7页
Chinese Journal of Pharmaceuticals
关键词
磷脂
中空介孔二氧化硅纳米粒
姜黄素
递药系统
突释
生物利用度
phospholipid
hollow mesoporous silica nanoparticle
curcumin
drug delivery system
burst release
bioavailability
作者简介
程子明(1987-),男,工程师,从事制药生产与检测方向的研究。E-mail:409447154@qq.com。
