摘要
目的:通过桔梗宏观性状(长、宽、厚、质量)、微观形状(乳汁管面积)以及桔梗总皂苷和镇咳祛痰作用的关联分析,探究基于桔梗“形”的“辨状论质”实质。方法:本研究对桔梗“状”中的“形”、桔梗总皂苷和镇咳祛痰的药效结果进行定量测定,分别进行“状-量-效”和“状-效”关联分析,讨论“形”与桔梗品质的关系。结果:不同来源桔梗“形”的量化值、总皂苷含量和镇咳祛痰量化结果均有一定差异。“状-量-效”关联结果显示桔梗质量可体现药材品质,“状-效”关联结果显示宽度、厚度和乳汁管面积均与咳嗽次数呈显著相关,桔梗质量与酚红排泄量呈显著相关。结论:桔梗总皂苷可体现桔梗药材品质。“状-效”和“状-量-效”关联分析均可体现“辨状论质”的实质,其中“状-效”分析更明确、针对性更强。
Objective:By analyzing the macroscopic characteristics(length,width,thickness,and weight),microscopic shape(milk duct area),and the correlation between total saponins of Jiegeng(Platycodon grandiflorum)and its antitussive and expectorant effects,this study explores the essence of the"Feature Identification Based Quality Assessment"based on the"Shape"of Jiegeng(Platycodon grandiflorum).Methods:This study quantitatively measured the"Shape",total saponins of Platycodon grandiflorum,and the efficacy of antitussive and expectorant drugs in the"Form"of Jiegeng(Platycodon grandiflorum),and conducted"Form-Quantity-Effect"and"Form-Effect"correlation analysis,respectively,to discuss the relationship between"Shape"and the quality of Jiegeng(Platycodon grandiflorum).Results:There are certain differences in the quantitative values of"Shape",total saponin content,and antitussive and expectorant quantitative results of different sources of Jiegeng(Platycodon grandiflorum).The"Form-Quantity-Effect"correlation results showed that the weight of Jiegeng(Platycodon grandiflorum)can reflect the quality of the medicinal material.The"Form-Effect"correlation results showed that the width,thickness,and area of the milk duct were significantly correlated with the number of coughs,and that the weight of Jiegeng(Platycodon grandiflorum)was significantly correlated with the excretion of phenol red.Conclusions:The total saponins of Jiegeng(Platycodon grandiflorum)can reflect the quality of Jiegeng(Platycodon grandiflorum)medicinal materials.The correlation analysis of"Form-Effect"and"Form-Quantity-Effect"can reflect the essence of"Feature Identification Based Quality Assessment",and"Form-Effect"analysis is more clear and targeted.
作者
王冰
孙艳涛
康廷国
WANG Bing;SUN Yantao;KANG Tingguo(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian Liaoning 116600,China)
出处
《中医药导报》
2024年第6期49-52,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
辽宁省自然科学基金项目(2022-BS-204)。
关键词
桔梗
辨状论质
“状-量-效”关联
“状-效”关联
Jiegeng(Platycodon grandiflorum)
Feature Identification Based Quality Assessment
"Form-Quantity-Effect"correlation
"Form-Effect"correlation
作者简介
通信作者:孙艳涛,男,副教授,研究方向为中药配伍机制和中药活性成分筛选。
