摘要
The standard approach to organ preservation in liver transplantation is by static cold storage and the time between the cross-clamping of a graft in a donor and its reperfusion in the recipient is defined as cold ischemia time(CIT).This simple definition reveals a multifactorial time frame that depends on donor hepatectomy time,transit time,and recipient surgery time,and is one of the most important donor-related risk factors which may influence the graft and recipient’s survival.Recently,the growing demand for the use of marginal liver grafts has prompted scientific exploration to analyze ischemia time factors and develop different organ preservation strategies.This review details the CIT definition and analyzes its different factors.It also explores the most recent strategies developed to implement each timestamp of CIT and to protect the graft from ischemic injury.
作者简介
Corresponding author:Manuela Cesaretti,MD,PhD,Assistant Professor,Surgeon,Department of HPB and Liver Transplantation,Brotzu Hospital,100 Boulevard du Général Leclerc,Cagliari 09122,Italy.manuela.csr02@gmail.com,ORCID number:0000-0001-6419-1481;Co-corresponding authors:Orestes Mavrothalassitis,ORCID number:0000-0002-2301-9682;Alessandro Izzo,ORCID number:0000-0002-6828-6768;Roberta Anna Pellegrino,ORCID number:0000-0003-4332-004X;Alessandro Galli,ORCID number:0000-0002-8818-3977.
