摘要
Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs.Extended criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this challenge.However,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold storage.Machine perfusion(MP)was designed to improve organ preservation and reduce posttransplant complications.Nevertheless,it is increasingly evident that MP alone may not preserve ECD grafts optimally.Increasing emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic interventions.Here,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD grafts.In this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.
基金
the National Key Research and Development Program of China(2021YFA1100500)
the Zhejiang University-Cambridge Global Partnership Fund
the National Natural Science Foundation of China(81930016 and 82003248)
the Key Research and Development Program of Zhejiang Province(2022C03108)
the Projects of Medical and Health Technology Program in Zhejiang Province(WKJZJ-2120).
作者简介
Corresponding authors:Kourosh Saeb-Parsy,E-mail addresses:ks10014@cam.ac.uk;Corresponding authors:Xiao Xu,E-mail addresses:zjxu@zju.edu.cn;Zhoucheng Wang,These authors contributed equally to this work and share the first authorship;Jack Martin,These authors contributed equally to this work and share the first authorship。
