摘要
目的观察阿替普酶溶栓联合丁苯酞软胶囊治疗对急性脑梗死患者的临床疗效及生活质量的改善作用。方法急性脑梗死患者80例随机均分为观察组和对照组,对照组予以阿替普酶静脉溶栓治疗,观察组予以阿替普酶静脉溶栓联合丁苯酞软胶囊治疗;于入院时、治疗后第6天、第12天时采用NIHSS量表(NIHSS)测评两组患者神经功能;于入院时、治疗后取血检测两组患者白细胞介素-6(IL-6)、C反应蛋白(CRP)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(FiB);采用改良RANKIN量表(mRS)评估两组患者生活质量。结果治疗后两组患者神经功能损伤均较治疗前有改善,观察组治疗后第6天、第12天时NIHSS评分均低于同期对照组(P<0.05);治疗后第12天时,观察组血清IL-6、CRP水平均低于同期对照组,mRS量表评分高于同期对照组(P<0.05)。结论急性脑梗死患者应用丁苯酞联合阿替普酶治疗效果佳,能提升患者生活质量。
Objective To analyze the curative effect of alteplase thrombolysis combined with butyrophthalide softgel capsulesin the clinical treatment of patients with acute cerebral infarction(ACI)and the effect of improving quality of life after illness.Methods A total of 80 patients with ACI were randomly divided into the reference group(40 cases)andthe experimental group(40 cases)after emergency admission,and the reference group was treated with intravenous thrombolysis of alepplase after the disease was diagnosed,and the intravenous thrombolysis of alteplase+butyranphthalide softgelsweretaken in the experimental group.The neurological function of the patients was assessed by the NIH Stroke Scale(NIHSS)at admission and 6 and 12 days after treatment.The values of interleukin6(IL-6),C-reactive protein(CRP),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),and fibrinogen(FiB)in both groups were measured at admission and 12 days after treatment.Barthelindex of ADL was used to evaluate the quality of life of the two groups and the modified RANKIN Scale(mRS)was used toassess the prognosis of the two groups at admission and 12 days after treatment.Results After treatment,the neurological impairment ofthepatients was improved,and the NIHSS scores in the experimental group were lower than those in the reference group 6 and 12 days after treatment(all P<0.05);12 days after treatment,the blood IL-6,CRP were lower than those in the reference group in the same period(all P<0.05);12 days after treatment,the scores of mRS scales in the experimental group were higher than those in the reference group in the same period(all P<0.05).Conclusion Alteplase intravenous thrombolysis combined with butylphthalein softgel capsules can improve the quality of life of patients with acute cerebral infarction.
作者
乔启家
盛守权
施秀芳
QIAO Qijia;SHENG Shouquan;SHI Xiufang(Department of Neurology,the Second People's Hospital of Chizhou,Chizhou 247000,Anhui,China)
出处
《贵州医科大学学报》
CAS
2024年第5期769-773,共5页
Journal of Guizhou Medical University
基金
安徽省自然科学基金(2008085QH390)
安徽省高校科研项目(2023AH053142)。
关键词
丁苯酞软胶囊
阿替普酶
急性脑梗死
生活质量
神经功能
butylphthalide softgels capsule
altenplase
acute cerebral infarction
quality of life
neurological function
