摘要
目的:探讨熊氏十味温胆汤治疗稳定型心绞痛合并下肢动脉粥样硬化斑块(LLAS)的临床疗效。方法:采用随机数字表法将96例痰瘀互结型稳定型心绞痛合并LLAS患者分为治疗组和对照组,每组各48例。对照组采用西医常规治疗,治疗组在对照组基础上加服熊氏十味温胆汤。比较2组治疗前后的心绞痛症状积分、中医证候积分、生活质量、血脂指标[总胆固醇(TG)、三酰甘油(TC)]、超敏C反应蛋白(hs-CRP)、血液流变学指标(全血低切黏度、全血高切黏度、血小板聚集率)、下肢动脉彩超情况以及不良反应。结果:总有效率治疗组为97.91%(47/48),高于对照组的83.33%(40/48),差异有统计学意义(P<0.05)。2组治疗后心绞痛症状积分、中医证候积分、生活质量、血脂指标、hs-CRP、血液流变学指标(全血低切黏度、全血高切黏度、血小板聚集率)、下肢动脉彩超情况均较治疗前改善,且治疗组改善情况优于对照组,差异均有统计学意义(均P<0.05)。治疗过程中2组患者均未发生明显不良反应。结论:熊氏十味温胆汤治疗稳定型心绞痛合并LLAS疗效佳,安全性高,优于单纯使用西药治疗。
Objective:To investigate the clinical effect of Xiongshi Shiwei Wendan decoction in the treatment of stable angina with lower limb atherosclerosis(LLAS).Methods:A total of 96 patients with stable angina with LLAS and the syndrome of intermingled phlegm and blood stasis were divided into treatment group and control group using a random number table,with 48 patients in each group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group received Xiongshi Shiwei Wendan decoction in addition to the treatment in the control group.The two groups were compared in terms of angina pectoris symptom score,traditional Chinese medicine(TCM)syndrome score,quality of life,blood lipid parameters(total cholesterol[TC]and triglyceride[TG]),high-sensitivity C-reactive protein(hs-CRP),hemorheological indices(low-shear blood viscosity,high-shear blood viscosity,and platelet aggregation rate),color Doppler ultrasound of lower extremity arteries,and adverse reactions.Results:The treatment group had a significantly higher overall response rate than the control group[97.92%(47/48)vs 83.33%(40/48),P<0.05].Compared with the control group,the treatment group had significantly better improvements in angina pectoris symptom score,TCM syndrome score,quality of life,blood lipid parameters,hs-CRP,hemorheological indices(low-shear blood viscosity,high-shear blood viscosity,and platelet aggregation rate),and color Doppler ultrasound of lower extremity arteries after treatment(all P<0.05).No obvious adverse reactions were observed in either group during treatment.Conclusion:Xiongshi Shiwei Wendan decoction has a good clinical effect and a favorable safety profile in the treatment of stable angina with LLAS,with a better clinical effect than Western medicine treatment alone.
作者
袁玥
谢雪姣
YUAN Yue;XIE Xuejiao(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,Hunan,China)
出处
《湖南中医杂志》
2024年第4期1-5,共5页
Hunan Journal of Traditional Chinese Medicine
基金
湖南省自然科学基金项目(2021JJ30510)
湖南中医药大学校级研究生课题(2022XC167,2022CX168)。
关键词
稳定型心绞痛
下肢动脉粥样硬化斑块
痰瘀互结型
熊氏十味温胆汤
stable angina
lower limb atherosclerosis
syndrome of intermingled phlegm and blood stasis
Xiongshi Shiwei Wendan decoction
作者简介
第一作者:袁玥,女,2021级硕士研究生,研究方向:中医药防治心脑血管疾病;通信作者:谢雪姣,女,医学博士,教授,硕士研究生导师,研究方向:中医药防治心脑血管疾病,E-mail:wangkaiyueyue@163.com。
