摘要
目的:探讨扶正透邪解毒化瘀方对多重耐药铜绿假单胞菌肺炎老年大鼠炎症反应与免疫功能的态影响。方法:将实验老年大鼠随机分为空白对照组、模型对照组、西药对照组、中药组、中药提前给药组、中西医结合观察组,动态观察不同时间点各组老年大鼠炎症指标的变化及淋巴细胞增殖水平的变化。结果:中药提前给药组及中西医结合观察组疗效显著,中药组对感染早期的炎症水平改善明显;中西医结合观察组可使T淋巴细胞增殖能力趋于正常;中药提前给药组、中西医结合观察组能抑制感染后B淋巴细胞的增殖并使其趋于正常。结论:扶正透邪解毒化瘀方能够调节感染早期老年大鼠机体过度的免疫炎症反应,中西医结合治疗能够纠正多重耐药铜绿假单胞菌感染后紊乱的免疫状态,中药提前给药能够对多重耐药铜绿假单胞菌感染后的炎症反应及免疫紊乱起到一定的预防及治疗作用。
Objective:To study the effect of Fuzheng Touxie Jiedu Huayu Formula on inflammatory responses and immune function in elderly rats with pneumonia caused by multi-drug-resistant Pseudomonas aeruginosa.Methods:The experimental elderly rats were randomly divided into six groups:blank control group,model control group,western medicine control group,traditional Chinese medicine(TCM)group,pre-medication TCM group,and integrated traditional Chinese medicine and western medicine treatment group.The study dynamically observed changes in inflammation markers and lymphocyte proliferation levels at different time points across the groups.Results:Significant therapeutic effects were observed in both the pre-medication TCM group and the integrated treatment group,and the TCM group showed notable improvements in early-stage inflammation levels;the integrated treatment group helped T lymphocyte proliferation approach normal levels;the pre-medication TCM group and the integrated treatment group were able to suppress post-infection B lymphocyte proliferation and normalize it.Conclusion:Fuzheng Touxie Jiedu Huayu Formula can modulate the excessive immune-inflammatory reaction of elderly rats in the early stage of infection,and the integrated traditional Chinese and western medicine treatment can correct the disordered immune state after infection with multidrug-resistant P.aeruginosa.Pre-medication of TCM can play a preventive and therapeutic role in the inflammation and immune dysregulation following such infections.
作者
王亚杰
徐红日
马洁
刘国星
曹鸿云
刘通
郝丹丹
刘凤仪
杨丽娟
WANG Yajie;XU Hongri;MA Jie;LIU Guoxing;CAO Hongyun;LIU Tong;Hao Dandan;LIU Fengyi;YANG Lijuan(Beijing University of Chinese Medicine Third Affiliated Hospital Emergency Department and ICU,Beijing 100029,China;Beijing Hospital of Integrated Chinese and Western medicine Respiratory department,Beijing 100038,China;Linwei Liu Zunji TCM Clinic Weinan,Weinan 714000,China;Beijing Dong zhi men Hospital ICU,Beijing 100700,China;Beijing University of Traditional Chinese Medicine,Beijing 100105,China)
出处
《世界中医药》
CAS
北大核心
2024年第6期807-812,共6页
World Chinese Medicine
基金
国家自然科学基金项目(81473661)
北京中医药大学第三附属医院培育项目(BZYSY-2022-PYMS-16)
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202208)
北京市自然科学基金项目(7232285)。
关键词
扶正透邪解毒化瘀方
多重耐药铜绿假单胞菌肺炎
老年
大鼠
炎症指标
淋巴细胞增值
免疫
体内实验
Fuzheng Tongxie Jiedu Huayu Formula
Multi-drug Resistant Pseudomonas aeruginosa Pneumonia
Elderly
Rats
Inflammatory indicators
Lymphocyte Proliferation
Immunization
In vivo experiments
作者简介
王亚杰(1988.08-),女,博士后,主治医师,研究方向:中医药治疗呼吸系统疾病,E-mail:xiaoyaoren8807@126.com;通信作者:徐红日(1976.07-),男,博士,主任医师,研究生导师,博士后合作导师,研究方向:中医药防治呼吸系统感染性疾病的临床与基础研究,E-mail:2935856242@qq.com;通信作者:马洁(1988.10-),女,博士,主治医师,研究方向:中医药防治呼吸系统疾病,E-mail:shandongmajie@sina.com。
