摘要
目的研究在治疗小儿支气管肺炎时采用肺力咳合剂联合盐酸氨溴索的临床实验效果。方法选择160例小儿支气管肺炎患者进行实验,选取患儿的时间间隔为2021年2月至2023年4月,将其平均分成两组,分别为对照组和联合组,其中对照组80例患儿,联合组80例患儿。所有的患儿接受的治疗方式都为日常常规治疗,对照组患儿给予盐酸氨溴索治疗,联合组采用肺力咳合剂联合盐酸氨溴索治疗。比较两组患者的临床疗效、相关症状体征消失时间、血气指标[动脉血氧分压(PO_(2))、二氧化碳分压(PCO_(2))、血氧饱和度(SaO_(2))]、分析治疗前后血清炎性因子[超敏c反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)]及不良反应的变化。结果治疗后,联合组总有效率(96.25%)高于对照组(87.50%),差异有统计学意义(P<0.05)。治疗后,联合组患者气短、痰多、发热、肺啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗前两组患儿PCO_(2)、PO_(2)、SaO_(2)对比均无统计学意义(P>0.05);治疗后两组患儿PO_(2)、SaO_(2)较治疗之前均明显升高,PCO_(2)有所下降,且联合组患儿PO_(2)、SaO_(2)高于对照组,PCO_(2)指标低于对照组(P<0.05)。治疗前两组患儿hs-CRP、TNF-α及IL-6对比均无统计学意义(P>0.05);治疗后联合组血清hs-CRP、TNF-α及IL-6水平低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论肺力咳合剂联合盐酸氨溴索对小儿支气管肺炎的治疗效果显著,能有效缓解患儿喘促、咳痰、发热等临床症状及肺功能情况,改善机体炎性因子水平,促进肺部病灶的吸收。
Objective To study the clinical effect of Feilike mixture combined with ambroxol hydrochloride in the treatment of bronchophenitis in children.Methods A total of 160 children with bronchopneumonia were selected from February 2021 to April 2023,and were evenly divided into two groups:control group and combined group,with 80 children in the control group and 80 children in the combined group.All of the children were treated with the usual routine,the control group was treated with ambroxol hydrochloride,and the combined group was treated with Feilike mixture combined with ambroxol hydrochloride.The clinical efficacy,disappearance time of related symptoms and signs,blood gas index[partial pressure of arterial oxygen(PO_(2)),partial pressure of carbon dioxide(PCO_(2)),and blood oxygen saturation(SaO_(2))]of the two groups were compared,the changes of serum inflammatory factors[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and adverse reactions before and after treatment were analyzed.Results After treatment,the total effective rate of the combined group(96.25%)was higher than that of the control group(87.50%),and the difference was statistically significant(P<0.05).After treatment,the disappearance time of shortness of breath,phlegm,fever and lung rales in combined group was shorter than that in control group(P<0.05);There was no significant difference in PCO_(2),PO_(2)and SaO_(2)between the two groups before treatment(P>0.05).After treatment,PO_(2)and SaO_(2)in the two groups were higher than before treatment,and PCO_(2)was decreased,and PO_(2)and SaO_(2)in the combined group were higher than those in the control group,and PCO_(2)indexes were lower than those in the control group(P<0.05).There were no significant differences in hs-CRP,TNF-αand IL-6 between the two groups before treatment(P>0.05).After treatment,the serum levels of hs-CRP,TNF-αand IL-6 in combined group were lower than those in control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Feilike mixture combined with ambroxol hydrochloride has significant therapeutic effect on children with bronchopulmonary pneumonia,which can effectively relieve the clinical symptoms and lung function of children such as shortness of breath,expectoration,fever,improve the level of inflammatory factors,and promote the absorption of lung lesions,which is worthy of clinical application.
作者
廖贞球
LIAO Zhenqiu(Department of Pediatrics,Ninghua County General Hospital,Sanming 365400,China)
出处
《中国医药指南》
2024年第12期119-122,共4页
Guide of China Medicine
关键词
肺力咳合剂
盐酸氨溴索
支气管肺炎
儿童
安全性
Feilike mixture
Ambroxol hydrochloride
Bronchopneumonia
Children
Safety
