摘要
内质网(ER)是真核细胞最主要的膜性结构,是细胞内重要生理过程发生的关键细胞器。在多种内外因素的作用下,ER的稳态受到破坏,导致蛋白质加工运输受阻,未折叠蛋白或错误折叠蛋白在ER腔内聚集,形成内质网应激(ERS),并触发未折叠蛋白反应(UPR)。适度的ERS通过UPR信号通路减少蛋白质合成、促进蛋白质降解、增加协助蛋白质折叠的分子伴侣,最终缓解ER压力。但是,如果ERS过强或持续时间过长,超过细胞的自身调节能力时,UPR可启动细胞凋亡,亦可导致疾病。大量研究表明,ERS与多种心血管疾病(CVD)的发生发展密切相关。该综述主要阐述UPR在几种常见CVD中的研究进展和靶向UPR作为CVD的潜在治疗方法。
Endoplasmic reticulum(ER)is the predominant membrane structure in eukaryotic cells and is a key organelle for the occurrence of important intracellular physiological processes.Under the action of various internal and external factors,the homeostasis of ER is disrupted to block protein processing and transport,and the accumulation of unfolded or misfolded proteins in the ER lumen,forms endoplasmic reticulum stress(ERS)and triggers the unfolded protein response(UPR).Moderate ERS reduces protein synthesis,promotes protein degradation,and increases molecular chaperones that assist protein folding through the UPR signaling pathway,ultimately relieving ER stress.However,if the ERS is too strong or prolonged and exceeds the cell s ability to regulate itself,the UPR can initiate apoptosis and lead to diseases.Numerous studies have shown that ERS is closely associated with the development of several cardiovascular diseases(CVD).This review focuses on the research progress of UPR in several common types of CVD and targets UPR as a potential therapeutic approach for CVD.
作者
李亮
张梅
陈克明
LI Liang;ZHANG Mei;CHEN Keming(School of Life Science and Engineering,Lanzhou University of Technology;Basic Medicine Laboratory,the 940th Hospital of Joint Logistic Support Force of Chinese People s Liberation Army,Lanzhou,Gansu 730050,China)
出处
《中国动脉硬化杂志》
CAS
2024年第4期355-363,共9页
Chinese Journal of Arteriosclerosis
基金
中国人民解放军联勤保障部队第九四〇医院实验室培育项目(2021yxky081、2021yxky083)
全军动物实验专项[SYDW(2018)12号]
甘肃省自然科学基金实验动物专项(22JR5RA023)。
关键词
内质网应激
未折叠蛋白反应
心血管疾病
endoplasmic reticulum stress
unfolded protein response
cardiovascular disease
作者简介
李亮,硕士研究生,主要从事抗高原性心脏病药物研究,E-mail:318990025@qq.com;通信作者:陈克明,博士,主任技师,硕士研究生导师,主要从事内分泌腺及全身性疾病研究,E-mail:chenkm@lut.cn。
