摘要
目的通过Meta分析探索IgA肾病患者幽门螺杆菌(Hp)感染率以及根治Hp后对IgA肾病的影响。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Webof Science,收集建库至2023年7月30日发表的有关IgA肾病合并Hp感染和根治的回顾性队列研究。结果总共纳入18篇文献共1615例IgA肾病患者,Egger's回归显示无发表性偏倚,敏感性分析显示结果稳健,Meta分析结果显示,IgA肾病患者Hp感染率高于健康对照者(OR=1.51,95%CI1.13~2.02,P<0.05);IgA肾病患者中Hp根治组与未抗Hp常规治疗对照组临床指标比较:估算肾小球滤过率(eGFR)、血清肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白定量(24 h-UTP)、白蛋白(ALB)、总胆固醇(TC)变化差异均无统计学意义(P>0.05)。结论IgA肾病患者Hp感染率明显高于健康对照者,提示IgA肾病与Hp感染可能存在关联性;IgA肾病患者中Hp根治组与未抗Hp常规治疗对照组治疗前后临床指标无明显变化,有待进一步扩大样本量、延长随访时间观察结局指标差异。
Objective To explore the infection rate of Hp in patients with IgA nephropathy and the effect of radical Hp treatment on IgA nephropathy through meta-analysis.Methods Computer search China National Knowledge Network,Wanfang Database knowledge service platform,VIP network,China Biomedical Literature Database(CBM),PubMed,Embase,Cochrane Library,Web of Science,Retrospective cohort studies on IgA nephropathy with helicobacter pylori infection and radical treatment published until 2023-07-30 were collected.Results A total of 18 literatures were included,involving 1615 patients with IgA nephropathy.Egger's regression showed no publication bias,sensitivity analysis showed robust results,and Meta analysis showed:The infection rate of Hp in IgA nephropathy patients was higher than that in healthy controls(OR=1.51,95%CI 1.13-2.02,P<0.05).There were no significant differences in eGFR,Scr,BUN,24 h urinary protein,albumin and total cholesterol in IgA nephropathy patients between the Hp radical treatment group and the control group without anti-HP conventional treatment(P>0.05).Conclusion The infection rate of Hp in IgA nephropathy patients was significantly higher than that in healthy controls without nephropathy,suggesting that there may be a correlation between IgA nephropathy and Hp.There was no significant change in the clinical indexes of IgA nephropathy patients in the Hp radical treatment group and the control group without anti-HP conventional treatment before and after treatment.It is necessary to further expand the sample size and extend the follow-up period to observe the difference in outcome indexes.
作者
康琦
贾妮亚
王彩丽
范俊英
亢亚琴
KANG Qi;JIA Niya;WANG Caili;FAN Junying;KANG Yaqin(Inner Mongolia University of Science and Technology Baotou Medical College,Baotou 014040 China;Department of Nephrology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010 China)
出处
《内蒙古医学杂志》
2024年第1期35-42,共8页
Inner Mongolia Medical Journal
基金
自然科学一般项目(编号:NJZY22089)。
关键词
IGA肾病
幽门螺杆菌
IgA nephropathy
helicobacter pylori
作者简介
康琦,在读硕士研究生;通信作者:贾妮亚,E-mail:jnydodo@163.com。
