摘要
心力衰竭是高血压、缺血性心脏病、瓣膜性心脏病、冠心病等各种心血管事件常见的终末期临床表现,病理特征以进行性心功能不全和心肌重塑为主。姜黄素可通过抗心肌肥大和纤维化,增强细胞自噬,降低氧化应激反应,减轻心肌炎性损伤,调节Ca^(2+)-ATP酶活性,上调Dickkopf相关蛋白3的表达,多途径防治心力衰竭,进一步阻止心肌重塑,改善心功能。总结了姜黄素防治心力衰竭的研究情况,分析其作用机制,为姜黄素的临床运用提供支持。
Heart failure is a common end-stage clinical manifestation of various cardiovascular events,such as hypertension,ischemic heart disease,valvular heart disease,and coronary heart disease.Its pathological features are mainly progressive cardiac insufficiency and myocardial remodeling.Curcumin can inhibit myocardial hypertrophy and fibrosis,enhance autophagy,reduce oxidative stress,alleviate myocardial inflammatory damage,regulate Ca^(2+)-ATP ase activity,up-regulate DKK-3 expression,prevent and treat heart failure in multiple ways,further prevent myocardial remodeling,and improve cardiac function.This article summarizes the research progress of curcumin in prevention and treatment of heart failure,analyzes its mechanism of action,and provides support for the clinical application of curcumin.
作者
翁子山
陈建英
WENG Zishan;CHEN Jianying(Department of Structural Cardiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)
出处
《现代药物与临床》
CAS
2024年第2期536-540,共5页
Drugs & Clinic
作者简介
翁子山(1996-),男,在读研究生,规培医师,从事结构性心脏病临床和基础研究。E-mail:1979178574@qq.com;通信作者:陈建英(1969-),男,主任医师,从事结构性心脏病临床和基础研究。E-mail:jychen271@126.com。
