丹参多酚酸盐联合多索茶碱治疗慢性肺源性心脏病失代偿期患者的效果

Effects of Salvianolate combined with Doxofylline in treatment of patients with decompensated chronic pulmonary heart disease

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摘要目的:观察丹参多酚酸盐联合多索茶碱治疗慢性肺源性心脏病(肺心病)失代偿期患者的效果。方法:选取2021年1月至2023年5月该院收治的78例慢性肺心病失代偿期患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各39例。对照组给予多索茶碱治疗,观察组在对照组基础上联合丹参多酚酸盐治疗,比较两组临床疗效、治疗前后血气指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]水平、心肺功能指标[第1秒用力呼气容积(FEV1)、最大通气量(MVV)、左心室射血分数(LVEF)]水平、炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平和不良反应发生率。结果:两组治疗总有效率和不良反应发生率比较,差异均无统计学意义(P>0.05);治疗后,观察组PaO_(2)、FEV1、MVV、LVEF水平均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05);观察组IL-6、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05)。结论:丹参多酚酸盐联合多索茶碱治疗慢性肺心病失代偿期患者可提高心肺功能指标水平,改善血气指标水平,降低炎性指标水平,效果优于单纯多索茶碱治疗。 Objective:To observe effects of Salvianolate combined with Doxofylline in treatment of patients with decompensated chronic pulmonary heart disease(cor pulmonale).Methods:A prospective study was conducted on 78 patients with decompensated chronic pulmonary heart disease admitted to this hospital from January 2021 to May 2023.According to the random number table method,they were divided into control group and observation group,39 cases in each group.The control group was treated with Doxofylline,while the observation group was treated with Salvianolate on the basis of that of the control group.The clinical efficacy,the blood gas indexes levels[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2))],the cardiopulmonary function indexes levels[forced expiratory volume in one second(FEV1),maximum ventilation volume(MVV),left ventricular ejection fraction(LVEF)],the inflammatory factor levels[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:There were no significant differences in the total effective rate and the incidence of adverse reactions between the two groups(P>0.05).After the treatment,the levels of PaO_(2),FEV1,MVV and LVEF in the observation group were higher than those in the control group,the level of PaCO_(2) was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,TNF-αand hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Salvianolate combined with Doxofylline can improve the levels of cardiopulmonary function indexes,improve the levels of blood gas indexes and reduce the levels of inflammatory factors in the patients with decompensated chronic pulmonary heart disease.Moreover,it is superior to single Doxofylline treatment.

作者王艳丽 WANG Yanli(Department of Internal Medicine of Kaifeng Central Hospital,Kaifeng 475000 Henan,China)

机构地区开封市中心医院内科

出处《中国民康医学》 2024年第5期93-96,共4页 Medical Journal of Chinese People’s Health

关键词丹参多酚酸盐多索茶碱肺源性心脏病失代偿期心肺功能炎症反应不良反应 Salvianolate Doxofylline Pulmonary heart disease Decompensated period Cardiopulmonary function Inflammatory reaction Adverse reaction

分类号 R541.5 [医药卫生—心血管疾病]

作者简介王艳丽(1986.01-),女,汉族,河南开封人,本科,主治医师,研究方向为内科慢性疾病治疗。