摘要
目的探讨多索茶碱联合沙丁胺醇对慢性阻塞性肺疾病(COPD)患者的影响。方法选择我院2021年1月-2022年10月收治的104例COPD患者为研究对象,按随机数字表法将其分为对照组与观察组,每组52例。对照组在常规治疗基础上采用硫酸沙丁胺醇吸入气雾剂,观察组在对照组基础上采用多索茶碱片治疗。对比两组患者的血清相关指标、临床疗效、肺功能、血气指标及临床症状缓解时间。结果观察组治疗总有效率为94.23%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6、白细胞介素-18和肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05);观察组第1秒用力呼气容积、用力肺活量、呼气峰值流速均大于对照组,组间差异有统计学意义(P<0.05);观察组血氧分压、血氧饱和度均高于对照组,二氧化碳分压低于对照组,组间差异有统计学意义(P<0.05);观察组咳嗽缓解时间、咳痰缓解时间、气短缓解时间均短于对照组,组间差异有统计学意义(P<0.05)。结论多索茶碱联合沙丁胺醇治疗COPD患者可以有效降低血清炎性因子水平,具有改善患者的血气指标和肺功能,加快临床症状缓解速度,临床疗效高。
Objective To explore the effect of doxthelline and salbutamol in patients with chronic obstructive pulmonary disease(COPD).Methods 104 COPD patients admitted to our hospital from January 2021 to October 2022 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 52 cases in each group.The control group was treated with salbutamol sulfate inhalation aerosol on the basis of conventional treatment,and the observation group was treated with doxofylline tablets on the basis of control group.Serum related indexes,clinical efficacy,lung function,blood gas indexes and clinical symptom remission time were compared between the two groups.Results The total effective rate of the observation group was 94.23%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6,interleukin-18 and tumor necrosis factor-α in observation group were lower than those in control group,and the differences were statistically significant(P<0.05);forced expiratory volume,forced vital capacity and peak expiratory flow rate at the first second in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);blood oxygen partial pressure and blood oxygen saturation in observation group were higher than those in control group,and carbon dioxide fraction was lower than those in control group,with statistical significances between the two groups(P<0.05);the cough relief time,expectoration relief time and shortness of breath relief time in the observation group were shorter than those in the control group,and the differences were statistically significant between the two groups(P<0.05).Conclusion The treatment of doxophylline with albuterol can effectively reduce the level of serum inflammatory factors,improve the blood gas index and lung function of patients,accelerate the remission of clinical symptoms,and have high clinical efficacy.
作者
姚树鹏
YAO Shupeng(Department of Respiratory Medicine,Dongchangfu People's Hospital,Liaocheng City,Shandong Province,Liaocheng Shandong,252000,China)
出处
《反射疗法与康复医学》
2023年第21期74-77,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性阻塞性肺疾病
多索茶碱
沙丁胺醇
血清相关指标
肺功能
Chronic obstructive pulmonary disease
Dosotheophylline
Salbutamol
Serum related indicators
Lung function
作者简介
姚树鹏(1980-),男,山东聊城人,本科,副主任医师,研究方向:呼吸系统肺部感染诊治。
