摘要
方剂配伍包含了君臣佐使配伍、七情配伍、药性配伍(四气五味、升降浮沉、性味归经)。古代将一切治疗疾病的药物统称为毒药,按不良反应大小来分;现代则是以对人体不良影响为不良反应。增效即是相须相使,减毒即是相畏相杀。现回顾近年来相关文献,从方剂有毒药物配伍增效减毒内涵、规律和现代科技增效减毒新工艺为3个方面,重点从方剂有毒药物配伍增效减毒规律所包括的君臣佐使法,拆方法,药味、药量变化法,合方法,补脾护胃、顾护中气法、性效相制相成法等探讨方剂有毒药物配伍“增效减毒”的现代研究进展。
The compatibility of traditional Chinese medicine formulas involves the combination of king,minister,assistant,and envoy herbs,as well as considerations for seven emotions,drug properties(four qi,five flavors,ascending,descending,floating,sinking,and the nature and taste returning to specific meridians).In ancient times,all medicinal substances used for treating diseases were collectively referred to as toxic drugs,categorized based on the severity of adverse reactions.In modern times,toxicity is assessed based on adverse effects on the human body.Enhancing efficacy refers to the synergy between herbs,while reducing toxicity involves counteracting or neutralizing toxic effects.The authors reviewed related literature in recent years.The modern research progress on the compatibility of toxic drugs in traditional Chinese medicine formulas,focusing on“enhancing efficacy while reducing toxicity,”can be categorized into three aspects:the connotation,principles,and modern technological advancements.This includes exploring the rules of enhancing efficacy and reducing toxicity in the compatibility of toxic drugs in traditional Chinese medicine formulas,such as the use of king,minister,assistant,and envoy herbs,herb separation methods,variations in taste and dosage,combination methods,tonifying the spleen and protecting the stomach,safeguarding the middle qi,and the mutual restriction and enhancement of herb properties and effects.
作者
游雪娟
李丽青
冯珂
纪立金
YOU Xuejuan;LI Liqing;FENG Ke;JI Lijin(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Funeng Group General Hospital,Fuzhou 350122,China)
出处
《世界中医药》
CAS
北大核心
2024年第1期105-108,115,共5页
World Chinese Medicine
基金
国家自然科学基金面上项目(81373528)
福建省自然基金面上项目(2020J01739)。
关键词
方剂
有毒中药
配伍
增效
减毒
增效减毒
现代研究
研究进展
Prescription
Toxic Chinese medicine
Compatibility Of medicines
Enhancing efficacy
Reducing toxicity
Enhancing efficacy while reducing toxicity
Modern research
Research progress
作者简介
游雪娟(1993.07-),女,硕士研究生在读,研究方向:中医藏象脾胃与伤寒方向,E-mail:2582007124@qq.com;通信作者:纪立金(1964.07-),男,博士,教授,研究方向:中医藏象学脾胃与伤寒方向,E-mail:714642384@qq.com。
