摘要
BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and mortality.Soluble triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory processes.AIM To explore the prognostic value of sTREM-1 in patients with AD of cirrhosis.METHODS A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at admission.All enrolled patients were followed-up for at least 1 year.RESULTS In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD scores.Additionally,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d follow-up.The ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF development.CONCLUSION Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.
基金
National Natural Science Foundation of China,No.81970550,No.82070613 and No.82370638
Natural Science Foundation of Hunan Province,China,No.2021JJ31067 and No.2021JJ41048
Hunan innovative province construction project,No.2023JJ10095
Innovative Talented Project of Hunan province,China,No.2022RC1212.
作者简介
Corresponding author:Yan Huang,PhD,Professor,Department of Infectious Diseases,Hunan Key Laboratory of Viral Hepatitis,Xiangya Hospital,Central South University,No.87 Xiangya Road,Kaifu District,Changsha 110051,Hunan Provine,China.drhyan@csu.edu.cn,0000-0002-4747-3740;Co-corresponding authors:Ruo-Chan Chen,0000-0002-9079-0725;Hai Li,0000-0002-2510-5103;Guo-Hong Deng,0000-0003-1263-7220;Xian-Bo Wang,0000-0002-3593-5741;Xin Zheng,0000-0001-6564-7807;Jin-Jun Chen,0000-0003-4275-9149;Zhong-Ji Meng,0000-0003-0401-535X;Yu-Bao Zheng,0000-0002-2630-2563;Yan-Hang Gao 0000-0001-8590-6706;Zhi-Ping Qian,0000-0003-4641-3348;Feng Liu,0000-0001-7060-3710;Xiao-Bo Lu,0000-0001-5532-7551;Yu Shi,0000-0002-9392-7176;Jia Shang,0000-0001-9197-8773。
