摘要
髓系细胞触发受体-1是髓系细胞触发受体家族的成员,主要表达于髓系细胞表面。其放大炎症的作用已被广泛研究,分子机制涉及协同效应、细胞自噬、巨噬细胞极化、细胞焦亡等。随着研究的深入,发现髓系细胞触发受体-1在冠状动脉粥样硬化性心脏病、急性冠脉综合征、支架内再狭窄、缺血再灌注损伤等各个阶段发挥着举足轻重的作用,髓系细胞触发受体-1抑制剂有望成为新的冠心病治疗药物。现对髓系细胞触发受体-1的研究现状及其在冠心病中的研究进展做一综述,探讨其作为冠心病治疗靶标的可能性。
Triggering receptor expressed on myeloid cells-1(TREM-1)is a member of TREM family,mainly expressed on the surface of myeloid cells.Its role in amplifying inflammation has been widely studied,and its molecular mechanism involves synergistic effect,autophagy,macrophage polarization,pyroptosis and so on.With the development of research,it is found that TREM-1 plays an important role in coronary heart disease,acute coronary syndrome,in-stent restenosis,ischemia-reperfusion injury and other stages.TREM-1 inhibitor is expected to become a new drug for the treatment of coronary heart disease.In this paper,the research status of TREM-1 and its research progress in coronary heart disease will be reviewed,and the possibility of TREM-1 as a new drug for coronary heart disease will be discussed.
作者
蒋梦婷
张瑜
高磊
JIANG Mengting;ZHANG Yu;GAO Lei(Department of Cardiology,The Sixth Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Clinical Training Teaching Department of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《心血管病学进展》
CAS
2023年第4期345-349,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81970443)。
关键词
冠状动脉疾病
髓系细胞触发受体-1
炎症
Coronary artery disease
Triggering receptor expressed on myeloid cells-1
Inflammation
作者简介
通信作者:高磊,E-mail:nkgaolei2010@126.com。
