摘要
真实世界研究是指在较大样本量的基础上,根据患者的实际病情和意愿非随机选择治疗措施,以评价干预措施的外部有效性和安全性。真实世界研究在临床研究中得到越来越多的应用,其发展为中医学的科学研究提供了新方向。以真实世界研究为方法,可以发挥巨大的研究优势及价值。中医在治疗过程中具有经验性、个性化和异质性的特点,且中医的整体观与真实世界研究以患者为中心的观念相契合。另外,中国作为肝病大国,为肝病真实世界研究提供了充足的样本量,对于肝病的治疗优势独特。为了解真实世界研究中中医治疗肝病的研究进展,为中医肝病真实世界研究提供参考,文章检索和筛选相关文献,发现基于真实世界研究中医治疗肝病的中文文献有31篇,一是对临床药效的评价,如大黄?虫胶囊、软肝丸、鳖甲煎丸;二是关于肝病特定治疗方法的研究,如补肾生髓成肝法、益气和血法、毒痰瘀虚法;三是关于特定肝病的研究,涉及病种有肝炎、肝硬化、肝肿瘤及非酒精性脂肪肝,其中对慢性肝炎的研究最为深入;而对于名老中医经验方、病因病机、治疗应用方面及其余肝病种类方面研究相对空白,且科研团队的分布相对集中,对真实世界数据的使用还不充分,因此还具有很大的研究空间。
Real-world research refers to the non-random selection of treatment methods according to the actual condition and wishes of patients based on a larger sample size to evaluate the external effectiveness and safety of interventions.The real-world research has been applied more and more in clinical research,and its development provides new directions for the scientificR research of TCM.Using real-world research as a method can exert great research advantages and value.TCM has the characteristics of experience,individuality and heterogeneity in the treatment process,and the holistic view of TCM is in line with the patient-centered concept in the real world.In addition,as a large country with liver disease,China has provided sufficient sample size for the real world study of liver disease,and has unique advantages in the treatment of liver disease.In order to understand the research progress of treating liver disease in TCM in the real-world research,and to provide a reference for the real-world research on treating liver disease in TCM,the author searched and screened relevant literature and found that there were 31 Chinese literature of real-world research on TCM treatment of liver disease.These papers are mainly divided into 3 categories.The one is on the evaluation of clinical efficacy,such as the clinical efficacy of the Dahuang Zhechong capsules(大黄䗪虫胶囊),Ruangan Wan(软肝丸),Biejia Jian Wan(鳖甲煎丸).The second is the research on the specific treatment methods of liver diseases,such as the method of tonifying the kidney and generating marrow to form the liver,replenishing Qi(气)and blood method,and toxin-phlegm-blood stasis-deficiency method.The third is the research on specific liver diseases,involving hepatitis,cirrhosis,liver tumor and non-alcoholic fatty liver,among which chronic hepatitis is the most in-depth research.However,there are relatively fewer researches on the empirical prescriptions of famous TCM practitioners,etiology and pathogenesis,therapeutic applications and other types of liver diseases,and the distribution of scientific research teams is relatively concentrated.The use of real-world data is also not sufficient,so there is still a large research space.
出处
《中医临床研究》
2024年第2期91-97,共7页
Clinical Journal Of Chinese Medicine
基金
海南省省部共建先进技术临床医学研究中心项目(HNXJJS220002)。
关键词
真实世界
中医
肝病
Real world
TCM
Liver disease
作者简介
朱冉(1997-),女,2021级硕士研究生,研究方向为中医内科消化病研究;通讯作者:刘同亭(1970-),硕士,教授,博士生导师,研究方向为中西医结合诊治消化系统疾病基础与临床研究。
