摘要
目的:探讨慢性阻塞性肺病(Chronic obstructive pulmonary disease,COPD)合并呼吸衰竭患者血清胆碱酯酶(Cholinesterase,ChE)、前白蛋白(Prealbumin,PA)、高迁移率族蛋白B1(high mobility group protein B1,HMGB1)水平,分析其对预后的预测价值。方法:选取2021年1月至2022年12月本院收治的86例COPD合并呼吸衰竭患者为研究组,同时选取同期本院收治的82例单纯COPD患者为对照组,另选取同期于本院体检的健康志愿者56例为健康组。比较不同组别血清ChE、PA、HMGB1水平。研究组患者予以常规治疗,依据住院28 d内预后情况分为存活者、病死者。比较分析存活者、病死者治疗前、治疗7 d、治疗14 d后血清各指标水平,并分析其与急性生理学与慢性健康状况(Acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分相关性及其对预后的预测价值。结果:研究组血清ChE、PA水平低于对照组、健康组,HMGB1水平高于对照组、健康组(P<0.05);病死者治疗7 d、治疗14 d后血清ChE、PA水平低于存活者,HMGB1水平高于存活者(P<0.05);治疗7 d、14 d后血清ChE、PA、HMGB1预测预后的AUC大于单项指标预测,且治疗14 d后血清各指标联合预测预后的AUC大于治疗7 d后血清各指标联合预测(P<0.05)。结论:COPD合并呼吸衰竭不同病情程度、不同预后患者血清ChE、PA、HMGB1水平存在显著差异,且与APACHEⅡ评分密切相关,联合检测其水平对预后具有一定预测价值。
Objective:To investigate the serum levels of cholinesterase(ChE),prealbumin(PA)and high mobility group protein B1(HMGB1)in patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure,and analyze their predictive value for prognosis.Methods:86 COPD patients with respiratory failure admitted to our hospital from January 2021 to December 2022 were selected as the study group,while 82 simple COPD patients admitted to our hospital during the same period were selected as the control group,and 56 healthy volunteers who underwent physical examinations in our hospital during the same period were selected as the health group.Compare the levels of serum ChE,PA,and HMGB1 in different groups.The patients in the study group received routine treatment and were divided into survivors and deceased patients based on their prognosis within 28 days of hospitalization.The patients in the study group received routine treatment and were divided into survivors and deceased patients based on their prognosis within 28 days of hospitalization.Compare and analyze the serum levels of various indicators among survivors and deceased patients before treatment,7 days after treatment,and 14 days after treatment,and to analyze their correlation with acute physiology and chronic health evaluationⅡ(APACHEⅡ)and their predictive value for prognosis.Results:The levels of ChE and PA in the study group were lower than those in control group and healthy group,and the levels of HMGB1 were higher than those in control group and healthy group(P<0.05).After 7 days and 14 days of treatment,the serum ChE and PA levels of the deceased were lower than those of the survivors,while HMGB1 levels were higher than those of the survivors(P<0.05).The AUC of ChE,PA and HMGB1 in predicting prognosis was greater than that of single index after 7 and 14 days of treatment,and the AUC of combined serum indexes in predicting prognosis after 14 days of treatment was greater than that of combined serum indexes after 7 days of treatment(P<0.05).Conclusion:There are significant differences in serum ChE,PA and HMGB1 levels in patients with COPD combined with respiratory failure with different disease severity and prognosis,and they are closely related to APACHEⅡscore.Combined detection of CHE,PA and HMGB1 levels has certain predictive value for prognosis.
作者
郭玉
Guo Yu(Department of Respiratory and Critical Care Medicine,The First People's Hospital of Shangqiu City,Shangqiu 476000,Henan,China)
出处
《四川生理科学杂志》
2024年第2期332-335,共4页
Sichuan Journal of Physiological Sciences
关键词
慢性阻塞性肺病
呼吸衰竭
胆碱酯酶
前白蛋白
高迁移率族蛋白B1
Chronic obstructive pulmonary disease
Respiratory failure
Cholinesterase
Proalbumin
High mobility group protein B1
作者简介
郭玉,女,主治医师,主要从事呼吸与危重症医学研究,Email:wyj896@55455.org。
