摘要
目的探讨支气管肺泡灌洗术对尘肺患者肺功能及血清炎症因子水平的影响。方法选取2011年4月至2020年10月泰安市中心医院分院收治的92例尘肺患者作为研究对象,所有患者均进行支气管肺泡灌洗术治疗,比较治疗前后患者呼吸系统症状、肺功能指标、血气分析指标及血清炎症因子变化情况。结果治疗后,尘肺患者咳嗽、咳痰症状评分高于治疗前,胸闷、呼吸困难症状评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,尘肺患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最高呼气流速(PEF)、最大通气量(MVV)高于治疗前,差异有统计学意义(P<0.05),25%肺活量时最大呼气流速(MEF25%)、50%肺活量时最大呼气流速(MEF50%)、75%肺活量时最大呼气流速(MEF75%)与治疗前比较差异无统计学意义。治疗后,尘肺患者动脉血氧分压(PaO_(2))、pH高于治疗前,二氧化碳分压(PaCO_(2))、PaO_(2)/吸入气氧浓度(FiO_(2))低于治疗前,差异有统计学意义(P<0.05)。治疗后,尘肺患者肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)低于治疗前,白细胞介素-10(IL-10)高于治疗前,差异有统计学意义(P<0.05)。结论支气管肺泡灌洗术治疗尘肺病效果显著,可有效改善患者肺功能,调节炎症因子水平,减轻肺组织纤维化程度。
Objective To investigate the effect of bronchoalveolar lavage on lung function and serum inflammatory factors in patients with pneu-moconiosis.Methods A total of 92 patients with pneumoconiosis who were admitted to our hospital from January 2010 to August 2021 were select-ed as the research subjects,all patients were treated with bronchoalveolar lavage,the respiratory symptoms,pulmonary function indexes,blood gas analysis indicators and serum inflammatory factors were compared before and after treatment in patients.Results After treatment,the symptom scores of cough and sputum in pneumoconiosis patients were higher than before treatment,and the symptom scores of chest tightness and dyspnea were lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,forced vital capacity(FVC),forced expi-ratory volume in one second(FEV1),and peak expiratory velocity flow(PEF)and maximum gas volume(MVV)of pneumoconiosis patients were higher than those before treatment,and the difference was statistically significant(P<0.05).The Maximum expiratory flow rate 25%(MEF25%),MEF50%and MEF75%were not significantly different from those before treatment.After treatment,the partial pressure of oxygen(PaO_(2))and pH of pneumoconiosis patients were higher than those before treatment,the partial pressure of carbon dioxide(PaCO_(2))and PaO_(2)/fraction of inspire oxy-gen(FiO_(2))were lower than before treatment,and the differences were statistically significant(P<0.05).After treatment,the tumor necrosis factorα(TNF-α)and transforming growth factorβ1(TGF-β1)of pneumoconiosis patients were lower than before treatment,interleukin-10(IL-10)was high-er than that before treatment,and the difference was statistically significant(P<0.05).Conclusion Bronchoalveolar lavage is effective in the treat-ment of pneumoconiosis,which can effectively improve the lung function,regulate the level of inflammatory factors and reduce the degree of pulmo-nary fibrosis.
作者
张淑娟
ZHANG Shujuan(Department of Quality Management,Tai'an Central Hospital,Tai'an,Shandong,271000,China)
出处
《当代医学》
2023年第34期121-124,共4页
Contemporary Medicine
关键词
尘肺
支气管肺泡灌洗术
肺功能
血清炎症因子
Pneumoconiosis
Bronchoalveolar lavage
Lung function
Serum inflammatory factor
